Galichet, Arnaud; Borradori, Luca; Müller, Eliane Jasmine (2014). A new light on an old disease: adhesion signaling in pemphigus vulgaris. Journal of Investigative Dermatology, 134(1), pp. 8-10. Nature Publishing 10.1038/jid.2013.439
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Disruption of desmosomal cadherin adhesion leads to the activation of intracellular signaling pathways that are responsible for blister formation in pemphigus vulgaris (PV). Recent studies corroborate the implication of the p38 mitogen-activated protein kinase in PV blistering via its downstream effector mitogen-activated protein kinase activated protein kinase 2. These insights highlight the key role of cadherins in tissue homeostasis and are expected to change pemphigus management.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Research Foci > DermFocus 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) |
UniBE Contributor: |
Galichet, Arnaud; Borradori, Luca and Müller, Eliane Jasmine |
Subjects: |
600 Technology > 630 Agriculture 600 Technology > 610 Medicine & health |
ISSN: |
0022-202X |
Publisher: |
Nature Publishing |
Language: |
English |
Submitter: |
Monika Schenk |
Date Deposited: |
09 Apr 2015 11:48 |
Last Modified: |
22 Oct 2015 08:52 |
Publisher DOI: |
10.1038/jid.2013.439 |
PubMed ID: |
24352077 |
BORIS DOI: |
10.7892/boris.59186 |
URI: |
https://boris.unibe.ch/id/eprint/59186 |
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