Kakeda, Masato; Arock, Michel; Schlapbach, Christoph; Yawalkar, Nikhil (2014). Increased expression of heat shock protein 90 in keratinocytes and mast cells in patients with psoriasis. Journal of the American Academy of Dermatology, 70(4), 683-690.e1. Elsevier 10.1016/j.jaad.2013.12.002
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BACKGROUND
Psoriasis is a chronic inflammatory skin disease and various stress factors mediate inflammation. Heat shock protein (HSP) 90 plays an important role in cell survival; cytokine signaling, such as interleukin-17 receptor signaling; and immune responses.
OBJECTIVE
We sought to elucidate protein expression and distribution of HSP90 in psoriasis.
METHODS
HSP90 expression and its cellular source were analyzed on normal-appearing, nonlesional, lesional, and ustekinumab-treated psoriatic skin using immunohistochemistry and double immunofluorescence.
RESULTS
HSP90α, the inducible isoform of HSP90, was significantly up-regulated in epidermal keratinocytes and mast cells of lesional skin and down-regulated after ustekinumab therapy.
LIMITATIONS
There was a limited sample size.
CONCLUSIONS
HSP90 from keratinocytes and mast cells is a key regulator of psoriatic inflammation and HSP90 inhibitors may represent a novel therapeutic approach to the disease.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Kakeda, Masato, Schlapbach, Christoph, Yawalkar, Nikhil |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0190-9622 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Monika Schenk |
Date Deposited: |
16 Apr 2015 16:16 |
Last Modified: |
05 Dec 2022 14:37 |
Publisher DOI: |
10.1016/j.jaad.2013.12.002 |
PubMed ID: |
24521827 |
Uncontrolled Keywords: |
heat shock protein; heat shock protein 90; heat shock protein 90 inhibitor; keratinocytes; mast cells; psoriasis |
BORIS DOI: |
10.7892/boris.59190 |
URI: |
https://boris.unibe.ch/id/eprint/59190 |
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