Increased expression of heat shock protein 90 in keratinocytes and mast cells in patients with psoriasis.

Kakeda, Masato; Arock, Michel; Schlapbach, Christoph; Yawalkar, Nikhil (2014). Increased expression of heat shock protein 90 in keratinocytes and mast cells in patients with psoriasis. Journal of the American Academy of Dermatology, 70(4), 683-690.e1. Elsevier 10.1016/j.jaad.2013.12.002

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BACKGROUND Psoriasis is a chronic inflammatory skin disease and various stress factors mediate inflammation. Heat shock protein (HSP) 90 plays an important role in cell survival; cytokine signaling, such as interleukin-17 receptor signaling; and immune responses. OBJECTIVE We sought to elucidate protein expression and distribution of HSP90 in psoriasis. METHODS HSP90 expression and its cellular source were analyzed on normal-appearing, nonlesional, lesional, and ustekinumab-treated psoriatic skin using immunohistochemistry and double immunofluorescence. RESULTS HSP90α, the inducible isoform of HSP90, was significantly up-regulated in epidermal keratinocytes and mast cells of lesional skin and down-regulated after ustekinumab therapy. LIMITATIONS There was a limited sample size. CONCLUSIONS HSP90 from keratinocytes and mast cells is a key regulator of psoriatic inflammation and HSP90 inhibitors may represent a novel therapeutic approach to the disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Kakeda, Masato; Schlapbach, Christoph and Yawalkar, Nikhil

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0190-9622

Publisher:

Elsevier

Language:

English

Submitter:

Monika Schenk

Date Deposited:

16 Apr 2015 16:16

Last Modified:

19 Oct 2015 11:30

Publisher DOI:

10.1016/j.jaad.2013.12.002

PubMed ID:

24521827

Uncontrolled Keywords:

heat shock protein; heat shock protein 90; heat shock protein 90 inhibitor; keratinocytes; mast cells; psoriasis

BORIS DOI:

10.7892/boris.59190

URI:

https://boris.unibe.ch/id/eprint/59190

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