Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity.

Schlapbach, Christoph; Gehad, Ahmed; Yang, Chao; Watanabe, Rei; Guenova, Emmanuella; Teague, Jessica E; Campbell, Laura; Yawalkar, Nikhil; Kupper, Thomas S; Clark, Rachael A (2014). Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity. Science translational medicine, 6(219), 219ra8. American Association for the Advancement of Science 10.1126/scitranslmed.3007828

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T helper type 9 (TH9) cells can mediate tumor immunity and participate in autoimmune and allergic inflammation in mice, but little is known about the TH9 cells that develop in vivo in humans. We isolated T cells from human blood and tissues and found that most memory TH9 cells were skin-tropic or skin-resident. Human TH9 cells coexpressed tumor necrosis factor-α and granzyme B and lacked coproduction of TH1/TH2/TH17 cytokines, and many were specific for Candida albicans. Interleukin-9 (IL-9) production was transient and preceded the up-regulation of other inflammatory cytokines. Blocking studies demonstrated that IL-9 was required for maximal production of interferon-γ, IL-9, IL-13, and IL-17 by skin-tropic T cells. IL-9-producing T cells were increased in the skin lesions of psoriasis, suggesting that these cells may contribute to human inflammatory skin disease. Our results indicate that human TH9 cells are a discrete T cell subset, many are tropic for the skin, and although they may function normally to protect against extracellular pathogens, aberrant activation of these cells may contribute to inflammatory diseases of the skin.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Schlapbach, Christoph and Yawalkar, Nikhil

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1946-6234

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Monika Schenk

Date Deposited:

16 Apr 2015 16:52

Last Modified:

19 Oct 2015 11:30

Publisher DOI:

10.1126/scitranslmed.3007828

PubMed ID:

24431112

BORIS DOI:

10.7892/boris.59191

URI:

https://boris.unibe.ch/id/eprint/59191

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