High expression of FOXP3 in primary melanoma is associated with tumour progression.

Gerber, A L; Münst, A; Schlapbach, Christoph; Shafighi, Maziar; Kiermeir, David; Hüsler, Rolf; Hunger, Robert (2014). High expression of FOXP3 in primary melanoma is associated with tumour progression. British journal of dermatology, 170(1), pp. 103-109. Wiley-Blackwell 10.1111/bjd.12641

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BACKGROUND The antitumour immune response plays an important role in the prognosis of melanoma. High numbers of circulating regulatory T cells have been associated with rapid disease progression. OBJECTIVES To assess the influence of forkhead box protein (FOXP)3, CD1a and langerin expression on the prognosis of primary melanoma. METHODS We analysed 185 primary melanomas by immunohistochemical staining for expression of the regulatory T-cell marker FOXP3 and the dendritic cell markers langerin and CD1a, and correlated marker expression with clinical outcome. RESULTS Disease-free survival and overall survival were significantly longer in patients expressing low levels of FOXP3 in the primary melanoma, whereas they were associated with high expression of CD1a. The negative prognostic value of FOXP3 expression was independent of the Breslow tumour thickness. Langerin expression did not correlate with the clinical outcome. CONCLUSIONS High expression of FOXP3 in the primary melanoma may be used as an additional independent prognostic marker for early tumour progression in patients with melanoma.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery > Plastic, Reconstructive and Aesthetic Surgery
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery

UniBE Contributor:

Schlapbach, Christoph; Shafighi, Maziar; Kiermeir, David; Hüsler, Rolf and Hunger, Robert

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0007-0963

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Monika Schenk

Date Deposited:

15 Apr 2015 11:28

Last Modified:

19 Oct 2015 11:30

Publisher DOI:

10.1111/bjd.12641

PubMed ID:

24116716

BORIS DOI:

10.7892/boris.59193

URI:

https://boris.unibe.ch/id/eprint/59193

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