Procerenone: a Fatty Acid Triterpenoid from the Fruit Pericarp of Omphalocarpum procerum (Sapotaceae)

Ngamgwe, RF; Yankam, R; Chouna, JR; Lanz, Christian; Furrer, Julien; Schürch, Stefan; Kaiser, M; Lenta, BN; Ngouela, S; Tsamo, E; Brenneisen, Rudolf Max (2014). Procerenone: a Fatty Acid Triterpenoid from the Fruit Pericarp of Omphalocarpum procerum (Sapotaceae). Iranian Journal of Pharmaceutical Research, 13(4), pp. 1425-1430. Shaheed Beheshti University, Tehran, Iran

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Phytochemical investigation of a dichloromethane-methanol (1:1) extract of the fruit pericarp of Omphalocarpum procerum which exhibited antiplasmodial activity during preliminary screening led to the isolation of the new fatty ester triterpenoid 3β-hexadecanoyloxy-28-hydroxyolean-12-en-11-one (1), together with five known compounds 2-6. The structure of the new compound as well as those of the known compounds was established by means of spectroscopic methods and by comparison with previously reported data. Compounds 1- 4 were evaluated in-vitro for their cytotoxicity against L6 cell lines and antiprotozoal activities against Plasmodium falciparum, Leishmania donovani, Trypanosoma brucei rhodesiense and Trypanosoma cruzi (species responsible for human malaria, visceral leishmaniasis, African trypanosomiasis and Chagas disease, respectively). The tested compounds showed weak to moderate antiprotozoal activity and, no significant effect was detected regarding their cytotoxic potency.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Phytopharmakologie, Bioanalytik & Pharmakokinetik (discontinued)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Phytopharmakologie, Bioanalytik & Pharmakokinetik (discontinued)

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Lanz, Christian; Furrer, Julien; Schürch, Stefan and Brenneisen, Rudolf Max

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1735-0328

Publisher:

Shaheed Beheshti University, Tehran, Iran

Language:

English

Submitter:

Julien Henri Lucien Furrer

Date Deposited:

17 Oct 2014 15:38

Last Modified:

27 Jan 2015 13:01

Uncontrolled Keywords:

Sapotaceae, Omphalocarpum procerum, Triterpenoid, Procerenone, Antiparasitic activity

URI:

https://boris.unibe.ch/id/eprint/59374

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