Genital chlamydia prevalence in Europe and in non-European high income countries: systematic review and meta-analysis

Redmond, Shelagh M; Alexander-Kisslig, Karin; Woodhall, Sarah C; van den Broek, Ingrid; van Bergen, Jan EAM; Ward, Helen; Uusküla, Anneli; Herrmann, Björn; Andersen, Berit; Götz, Hannelore M; Sfetcu, Otilia; Low, Nicola (2015). Genital chlamydia prevalence in Europe and in non-European high income countries: systematic review and meta-analysis. PLoS ONE, 10(1), e0115753. Public Library of Science 10.1371/journal.pone.0115753

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Background: Accurate information about the prevalence of Chlamydia trachomatis is needed to assess national prevention and control measures. Methods: We systematically reviewed population-based cross-sectional studies that estimated chlamydia prevalence in European Union/European Economic Area (EU/EEA) Member States and non-European high income countries from January 1990 to August 2012. We examined results in forest plots, explored heterogeneity using the I2 statistic, and conducted random effects meta-analysis if appropriate. Metaregression was used to examine the relationship between study characteristics and chlamydia prevalence estimates. Results: We included 25 population-based studies from 11 EU/EEA countries and 14 studies from five other high income countries. Four EU/EEA Member States reported on nationally representative surveys of sexually experienced adults aged 18-26 years (response rates 52-71%). In women, chlamydia point prevalence estimates ranged from 3.0-5.3%; the pooled average of these estimates was 3.6% (95% CI 2.4, 4.8, I2 0%). In men, estimates ranged from 2.4-7.3% (pooled average 3.5%; 95% CI 1.9, 5.2, I2 27%). Estimates in EU/EEA Member States were statistically consistent with those in other high income countries (I2 0% for women, 6% for men). There was statistical evidence of an association between survey response rate and estimated chlamydia prevalence; estimates were higher in surveys with lower response rates, (p=0.003 in women, 0.018 in men). Conclusions: Population-based surveys that estimate chlamydia prevalence are at risk of participation bias owing to low response rates. Estimates obtained in nationally representative samples of the general population of EU/EEA Member States are similar to estimates from other high income countries.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Redmond, Shelagh and Low, Nicola

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Funders:

[54] European Centre for Disease Prevention and Control

Language:

English

Submitter:

Shelagh Redmond

Date Deposited:

03 Dec 2014 13:33

Last Modified:

08 Jun 2017 14:16

Publisher DOI:

10.1371/journal.pone.0115753

Related URLs:

PubMed ID:

25615574

Additional Information:

Manuscript Number PONE-D-14-37662R1

BORIS DOI:

10.7892/boris.60124

URI:

https://boris.unibe.ch/id/eprint/60124

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