Frontal white matter integrity is related to psychomotor retardation in major depression

Walther, Sebastian; Hügli, Simone; Höfle, Oliver; Federspiel, Andrea; Horn, Helge; Bracht, Tobias; Wiest, Roland; Strik, Werner; Müller, Thomas J (2012). Frontal white matter integrity is related to psychomotor retardation in major depression. Neurobiology of disease, 47(1), pp. 13-9. Amsterdam: Elsevier 10.1016/j.nbd.2012.03.019

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Altered frontal white matter integrity has been reported in major depression. Still, the behavioral correlates of these alterations are not established. In healthy subjects, motor activity correlated with white matter integrity in the motor system. To explore the relation of white matter integrity and motor activity in major depressive disorder, we investigated 21 medicated patients with major depressive disorder and 21 matched controls using diffusion tensor imaging and wrist actigraphy at the same day. Patients had lower activity levels (AL) compared with controls. Fractional anisotropy (FA) differed between groups in frontal white matter regions and the posterior cingulum. AL was linearly associated with white matter integrity in two clusters within the motor system. Controls had an exclusive positive association of FA and AL in white matter underneath the right dorsal premotor cortex. Only patients had a positive association within the posterior cingulum. Furthermore, patients had negative associations of FA and AL underneath the left primary motor cortex and within the left parahippocampal gyrus white matter. These differences in the associations between structure and behavior may contribute to well-known impaired motor planning or gait disturbances in major depressive disorder. Therefore, signs of psychomotor slowing in major depressive disorder may be linked to changes of the white matter integrity of the motor system.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse

UniBE Contributor:

Walther, Sebastian; Höfle, Oliver; Federspiel, Andrea; Horn, Helge Joachim; Bracht, Tobias; Wiest, Roland; Strik, Werner and Müller, Thomas Jörg

ISSN:

0969-9961

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:19

Last Modified:

19 Feb 2014 22:53

Publisher DOI:

10.1016/j.nbd.2012.03.019

PubMed ID:

22426387

Web of Science ID:

000304791700002

URI:

https://boris.unibe.ch/id/eprint/6014 (FactScience: 210906)

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