Tenascins in stem cell niches.

Chiquet-Ehrismann, Ruth; Orend, Gertraud; Chiquet, Matthias; Tucker, Richard P; Midwood, Kim S (2014). Tenascins in stem cell niches. Matrix biology, 37, pp. 112-123. Elsevier 10.1016/j.matbio.2014.01.007

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Tenascins are extracellular matrix proteins with distinct spatial and temporal expression during development, tissue homeostasis and disease. Based on their expression patterns and knockout phenotypes an important role of tenascins in tissue formation, cell adhesion modulation, regulation of proliferation and differentiation has been demonstrated. All of these features are of importance in stem cell niches where a precise regulation of growth versus differentiation has to be guaranteed. In this review we summarize the expression and possible functions of tenascins in neural, epithelial and osteogenic stem cell niches during normal development and organ turnover, in the hematopoietic and pro-inflammatory niche as well as in the metastatic niche during cancer progression.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics

UniBE Contributor:

Chiquet, Matthias

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0945-053X

Publisher:

Elsevier

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

21 Nov 2014 10:42

Last Modified:

25 Jan 2017 12:15

Publisher DOI:

10.1016/j.matbio.2014.01.007

PubMed ID:

24472737

Uncontrolled Keywords:

Cancer, Development, Hematopoiesis, Inflammation, Stem cell niche, Tenascin

BORIS DOI:

10.7892/boris.60250

URI:

https://boris.unibe.ch/id/eprint/60250

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