Localized Epidermal Cysts as a Radiation Recall Phenomenon in a Melanoma Patient Treated with Radiotherapy and the BRAF Inhibitor Vemurafenib

Houriet, Carine; Klass, Natalie Désirée; Beltraminelli, Helmut; Borradori, Luca; Oberholzer, Patrick Antony (2014). Localized Epidermal Cysts as a Radiation Recall Phenomenon in a Melanoma Patient Treated with Radiotherapy and the BRAF Inhibitor Vemurafenib. Case reports in dermatology, 6(3), pp. 213-217. Karger 10.1159/000367708

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BRAF inhibitors are broadly used for metastatic melanoma with BRAF mutations. Their use results in various cutaneous side effects, such as the development of keratoacanthomas and squamous cell carcinomas. We report a patient with metastatic melanoma treated with vemurafenib who developed dozens of histologically confirmed epidermal cysts within 2 months after initiation of vemurafenib administration. The cystic lesions were observed only in the localized area where a large exophytic melanoma tumor mass had been previously irradiated. Localized epidermal cysts may constitute an unusual radiation recall reaction in patients treated with BRAF inhibitors.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Houriet, Carine; Klass, Natalie Désirée; Beltraminelli, Helmut; Borradori, Luca and Oberholzer, Patrick Antony

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1662-6567

Publisher:

Karger

Language:

English

Submitter:

Monika Schenk

Date Deposited:

16 Apr 2015 11:14

Last Modified:

19 Apr 2015 03:32

Publisher DOI:

10.1159/000367708

PubMed ID:

25408648

Uncontrolled Keywords:

BRAF inhibitor, Epidermal cysts, Melanoma, Radiotherapy, Side effect, Vemurafenib

BORIS DOI:

10.7892/boris.60536

URI:

https://boris.unibe.ch/id/eprint/60536

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