Hypotension during fluid-restricted abdominal surgery: effects of norepinephrine treatment on regional and microcirculatory blood flow in the intestinal tract

Hiltebrand, Luzius B; Koepfli, Eliana; Kimberger, Oliver; Sigurdsson, Gisli H; Brandt, Sebastian (2011). Hypotension during fluid-restricted abdominal surgery: effects of norepinephrine treatment on regional and microcirculatory blood flow in the intestinal tract. Anesthesiology, 114(3), pp. 557-64. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/ALN.0b013e31820bfc81

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Vasopressors, such as norepinephrine, are frequently used to treat perioperative hypotension. Increasing perfusion pressure with norepinephrine may increase blood flow in regions at risk. However, the resulting vasoconstriction could deteriorate microcirculatory blood flow in the intestinal tract and kidneys. This animal study was designed to investigate the effects of treating perioperative hypotension with norepinephrine during laparotomy with low fluid volume replacement.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Brandt, Sebastian

ISSN:

0003-3022

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

04 Oct 2013 14:19

Last Modified:

23 Jan 2018 12:16

Publisher DOI:

10.1097/ALN.0b013e31820bfc81

PubMed ID:

21307765

Web of Science ID:

000287660300015

URI:

https://boris.unibe.ch/id/eprint/6059 (FactScience: 210952)

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