Dental and periodontal phenotype in sclerostin knockout mice.

Kuchler, Ulrike; Schwarze, Uwe Y; Dobsak, Toni; Heimel, Patrick; Bosshardt, Dieter; Kneissel, Michaela; Gruber, Reinhard (2014). Dental and periodontal phenotype in sclerostin knockout mice. International journal of oral science, 6(2), pp. 70-76. Sprinter Nature 10.1038/ijos.2014.12

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Sclerostin is a Wnt signalling antagonist that controls bone metabolism. Sclerostin is expressed by osteocytes and cementocytes; however, its role in the formation of dental structures remains unclear. Here, we analysed the mandibles of sclerostin knockout mice to determine the influence of sclerostin on dental structures and dimensions using histomorphometry and micro-computed tomography (μCT) imaging. μCT and histomorphometric analyses were performed on the first lower molar and its surrounding structures in mice lacking a functional sclerostin gene and in wild-type controls. μCT on six animals in each group revealed that the dimension of the basal bone as well as the coronal and apical part of alveolar part increased in the sclerostin knockout mice. No significant differences were observed for the tooth and pulp chamber volume. Descriptive histomorphometric analyses of four wild-type and three sclerostin knockout mice demonstrated an increased width of the cementum and a concomitant moderate decrease in the periodontal space width. Taken together, these results suggest that the lack of sclerostin mainly alters the bone and cementum phenotypes rather than producing abnormalities in tooth structures such as dentin.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Oral Surgery Research
04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology

UniBE Contributor:

Kuchler, Ulrike; Bosshardt, Dieter and Gruber, Reinhard

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2049-3169

Publisher:

Sprinter Nature

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

06 Jan 2015 16:38

Last Modified:

31 Jul 2019 08:25

Publisher DOI:

10.1038/ijos.2014.12

PubMed ID:

24699186

BORIS DOI:

10.7892/boris.60637

URI:

https://boris.unibe.ch/id/eprint/60637

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