The pharmacokinetics of dexmedetomidine administered as a constant rate infusion in horses.

Ranheim, B; Risberg, A I; Spadavecchia, Claudia; Landsem, R; Haga, H A (2014). The pharmacokinetics of dexmedetomidine administered as a constant rate infusion in horses. Journal of veterinary pharmacology and therapeutics, 38(1), pp. 93-96. Blackwell Scientific Publications 10.1111/jvp.12157

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Dexmedetomidine, the most selective α2 -adrenoceptor agonist in clinical use, is increasingly being used in both conscious and anaesthetized horses; however, the pharmacokinetics and sedative effects of this drug administered alone as an infusion are not previously described in horses. Seven horses received an infusion of 8 μg dexmedetomidine/kg/h for 150 min, venous blood samples were collected, and dexmedetomidine concentrations were assayed using liquid chromatography-mass spectrometry (LC/MS) and analyzed using noncompartmental pharmacokinetic analysis. Sedation was scored as the distance from the lower lip of the horse to the ground measured in centimetre. The harmonic mean (SD) plasma elimination half-life (Lambda z half-life) for dexmedetomidine was 20.9 (5.1) min, clearance (Cl) was 0.3 (0.20) L/min/kg, and volume of distribution at steady-state (Vdss ) was 13.7 (7.9) L/kg. There was a considerable individual variation in the concentration of dexmedetomidine vs. time profile. The level of sedation covaried with the plasma concentration of dexmedetomidine. This implies that for clinical use of dexmedetomidine constant rate infusion in conscious horses, infusion rates can be easily adjusted to effect, and this is preferable to an infusion at a predetermined value.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Anaesthesiology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)

UniBE Contributor:

Spadavecchia, Claudia

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

0140-7783

Publisher:

Blackwell Scientific Publications

Language:

English

Submitter:

Helene Rohrbach Rüegsegger

Date Deposited:

17 Dec 2014 16:36

Last Modified:

15 Oct 2015 09:17

Publisher DOI:

10.1111/jvp.12157

PubMed ID:

25229603

BORIS DOI:

10.7892/boris.60861

URI:

https://boris.unibe.ch/id/eprint/60861

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