Multidrug strategies are effective in the treatment of severe experimental pancreatitis

Werner, Jens; Hartwig, Werner; Hackert, Thilo; Kaiser, Heiko; Schmidt, Jan; Gebhard, Martha M; Büchler, Markus W; Klar, Ernst (2012). Multidrug strategies are effective in the treatment of severe experimental pancreatitis. Surgery, 151(3), pp. 372-81. New York, N.Y.: Elsevier 10.1016/j.surg.2011.07.041

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Trypsinogen activation, oxygen radicals, cytokines, leukocyte infiltration, and pancreatic ischemia are important steps in the pathogenesis of necrotizing pancreatitis and associated systemic complications. Several drugs that inhibit those pathogenetic steps attenuated biochemical and histologic changes, while survival remained low. The aim of the present study was to evaluate the benefit of multidrug approaches compared to monotherapies on organ injury and survival in acute experimental pancreatitis in the rat model of retrograde bile injection combined with intravenous cerulein.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Kaiser, Heiko Andreas

ISSN:

0039-6060

Publisher:

Elsevier

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

04 Oct 2013 14:19

Last Modified:

23 Jan 2018 12:16

Publisher DOI:

10.1016/j.surg.2011.07.041

PubMed ID:

21982067

Web of Science ID:

000301016500005

URI:

https://boris.unibe.ch/id/eprint/6097 (FactScience: 210993)

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