Nag, Sangram; Varrone, Andrea; Tóth, Miklós; Thiele, Andrea; Kettschau, Georg; Heinrich, Tobias; Lehmann, Lutz; Halldin, Christer (2012). In vivo evaluation in cynomolgus monkey brain and metabolism of [¹⁸F]fluorodeprenyl: a new MAO-B pet radioligand. Synapse, 66(4), pp. 323-30. New York, N.Y.: Wiley-Liss 10.1002/syn.21514
Full text not available from this repository.In this study, we evaluated the in vivo characteristics of a new monoamine oxidase type B (MAO-B) radioligand, [¹⁸F]fluorodeprenyl, by positron emission tomography (PET) in two cynomolgus monkeys. The brain uptake of [¹⁸F]fluorodeprenyl was more than 7% (600% SUV) of the total injected radioactivity and similar to that of [¹¹C]deprenyl, an established MAO-B radioligand. The highest uptake was observed in the striatum, one of the MAO-B-rich regions, with a peak at approximately 2-3 min after injection, followed by lower uptake in the thalamus and the cortex and lowest uptake in the cerebellum. Brain uptake of [¹⁸F]fluorodeprenyl was largely inhibited by preadministration of the MAO-B inhibitor, L-deprenyl, whereas clorgyline, a MAO Type A blocker, had no significant inhibitory effect, thus demonstrating selectivity for MAO-B. [¹⁸F]Fluorodeprenyl showed relatively slow metabolism with the presence of two radiometabolite peaks with similar retention time as the labeled metabolites of [¹¹C]deprenyl. These results suggest that [¹⁸F]fluorodeprenyl is a potential PET radioligand for visualization of MAO-B activity.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy |
UniBE Contributor: |
Lehmann, Lutz Eric |
ISSN: |
0887-4476 |
Publisher: |
Wiley-Liss |
Language: |
English |
Submitter: |
Jeannie Wurz |
Date Deposited: |
04 Oct 2013 14:19 |
Last Modified: |
05 Dec 2022 14:05 |
Publisher DOI: |
10.1002/syn.21514 |
PubMed ID: |
22124971 |
Web of Science ID: |
000299620200005 |
URI: |
https://boris.unibe.ch/id/eprint/6101 (FactScience: 210997) |
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