Perioperative nerve blockade: clues from the bench

Suter, M. R.; Siegenthaler, Andreas; Decosterd, I.; Ji, R. R. (2011). Perioperative nerve blockade: clues from the bench. Anesthesiology research and practice, 2011, p. 124898. Cairo (Egypt): Hindawi Publishing Corporation 10.1155/2011/124898

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Peripheral and neuraxial nerve blockades are widely used in the perioperative period. Their values to diminish acute postoperative pain are established but other important outcomes such as chronic postoperative pain, or newly, cancer recurrence, or infections could also be influenced. The long-term effects of perioperative nerve blockade are still controversial. We will review current knowledge of the effects of blocking peripheral electrical activity in different animal models of pain. We will first go over the mechanisms of pain development and evaluate which types of fibers are activated after an injury. In the light of experimental results, we will propose some hypotheses explaining the mitigated results obtained in clinical studies on chronic postoperative pain. Finally, we will discuss three major disadvantages of the current blockade: the absence of blockade of myelinated fibers, the inappropriate duration of blockade, and the existence of activity-independent mechanisms.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Siegenthaler, Andreas

ISSN:

1687-6962

Publisher:

Hindawi Publishing Corporation

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

04 Oct 2013 14:19

Last Modified:

23 Jan 2018 12:16

Publisher DOI:

10.1155/2011/124898

PubMed ID:

21776253

BORIS DOI:

10.7892/boris.6112

URI:

https://boris.unibe.ch/id/eprint/6112 (FactScience: 211012)

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