[Prophylaxis and therapy of postdural puncture headache--a critical evaluation of treatment options]

Kleine-Brüggeney, Maren; Kranke, Peter; Stamer, Ulrike M (2011). [Prophylaxis and therapy of postdural puncture headache--a critical evaluation of treatment options]. Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie, 46(7-8), pp. 516-24. Stuttgart: Thieme

Full text not available from this repository. (Request a copy)

Since the first description of spinal and epidural anaesthesia, postdural puncture headache (PDPH) is a well known complication. Its prophylaxis and treatment has been studied and discussed for more than 100 years, but the evidence is still limited. Due to relatively low prevalence of PDPH, prospective RCTs are often missing, and the frequently self-limiting character of PDPH impedes an adequate interpretation of results from studies without a control group. Taking side effects and complications into account, a prophylactic treatment of PDPH cannot be recommended. In case of PDPH, non-opioid analgesics are the first choice treatment. The epidural blood patch remains the mainstay of severe PDPH therapy. Noninvasive therapies like theophylline, sumatriptan and ACTH can be an alternative. However, an evidence-based recommendation is lacking. The development of standard operating procedures for accidental dural punctures and PDPH is recommended.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Kleine-Brüggeney, Maren and Stamer, Ulrike








Jeannie Wurz

Date Deposited:

04 Oct 2013 14:19

Last Modified:

23 Jan 2018 12:16

PubMed ID:


Web of Science ID:



https://boris.unibe.ch/id/eprint/6113 (FactScience: 211013)

Actions (login required)

Edit item Edit item
Provide Feedback