Retinal Laser Lesion Visibility in Simultaneous Ultra-High Axial Resolution Optical Coherence Tomography

Steiner, Patrick; Enzmann, Volker; Meier, Christoph; Povazay, Boris; Kowal, Horst Jens (2014). Retinal Laser Lesion Visibility in Simultaneous Ultra-High Axial Resolution Optical Coherence Tomography. IEEE Photonics Journal, 6(6), pp. 1-11. IEEE 10.1109/JPHOT.2014.2374594

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Ex vivo porcine retina laser lesions applied with varying laser power (20 mW–2 W, 10 ms pulse, 196 lesions) are manually evaluated by microscopic and optical coherence tomography (OCT) visibility, as well as in histological sections immediately after the deposition of the laser energy. An optical coherence tomography system with 1.78 um axial resolution specifically developed to image thin retinal layers simultaneously to laser therapy is presented, and visibility thresholds of the laser lesions in OCT data and fundus imaging are compared. Optical coherence tomography scans are compared with histological sections to estimate the resolving power for small optical changes in the retinal layers, and real-time time-lapse scans during laser application are shown and analyzed quantitatively. Ultrahigh-resolution OCT inspection features a lesion visibility threshold 40–50 mW (17 reduction) lower than for visual inspection. With the new measurement system, 42 of the lesions that were invisible using state-of-the-art ophthalmoscopic methods could be detected.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Image Guided Therapy > ARTORG Center - Ophthalmic Technology Lab
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Steiner, Patrick; Enzmann, Volker and Kowal, Horst Jens

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISSN:

1943-0655

Publisher:

IEEE

Language:

English

Submitter:

Patrick Steiner

Date Deposited:

19 Dec 2014 16:24

Last Modified:

19 Dec 2014 16:24

Publisher DOI:

10.1109/JPHOT.2014.2374594

Uncontrolled Keywords:

Image resolution,Laser applications, Lesions, Optical imaging, Retina, Retinal laser therapy, histology, optical coherence tomography, photocoagulation

BORIS DOI:

10.7892/boris.61132

URI:

https://boris.unibe.ch/id/eprint/61132

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