Stamer, Ulrike M; Lee, Eun-Hae; Rauers, Neele I; Zhang, Lan; Kleine-Brueggeney, Maren; Fimmers, Rolf; Stuber, Frank; Musshoff, Frank (2011). CYP2D6- and CYP3A-dependent enantioselective plasma concentrations of ondansetron in postanesthesia care. Anesthesia and analgesia, 113(1), pp. 48-54. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/ANE.0b013e31821d01bc
Full text not available from this repository. (Request a copy)An influence of polymorphic cytochromes P450 (CYP) 2D6 genetic variants on antiemetic efficacy of ondansetron has been suggested. However, the role of CYP3A in ondansetron metabolism and efficacy has been unclear. In this study, we evaluated the hypothesis that genotype-dependent CYP2D6 and CYP3A activity selectively influences plasma concentrations of ondansetron enantiomers. Additionally, the effects of doubling the ondansetron dose on genotype-dependent plasma concentrations were investigated.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy |
UniBE Contributor: |
Stamer, Ulrike, Stüber, Frank |
ISSN: |
0003-2999 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Jeannie Wurz |
Date Deposited: |
04 Oct 2013 14:19 |
Last Modified: |
05 Dec 2022 14:05 |
Publisher DOI: |
10.1213/ANE.0b013e31821d01bc |
PubMed ID: |
21596874 |
Web of Science ID: |
000291971900010 |
URI: |
https://boris.unibe.ch/id/eprint/6115 (FactScience: 211015) |
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