CYP2D6- and CYP3A-dependent enantioselective plasma concentrations of ondansetron in postanesthesia care

Stamer, Ulrike M; Lee, Eun-Hae; Rauers, Neele I; Zhang, Lan; Kleine-Brueggeney, Maren; Fimmers, Rolf; Stuber, Frank; Musshoff, Frank (2011). CYP2D6- and CYP3A-dependent enantioselective plasma concentrations of ondansetron in postanesthesia care. Anesthesia and analgesia, 113(1), pp. 48-54. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/ANE.0b013e31821d01bc

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An influence of polymorphic cytochromes P450 (CYP) 2D6 genetic variants on antiemetic efficacy of ondansetron has been suggested. However, the role of CYP3A in ondansetron metabolism and efficacy has been unclear. In this study, we evaluated the hypothesis that genotype-dependent CYP2D6 and CYP3A activity selectively influences plasma concentrations of ondansetron enantiomers. Additionally, the effects of doubling the ondansetron dose on genotype-dependent plasma concentrations were investigated.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Stamer, Ulrike and Stüber, Frank

ISSN:

0003-2999

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

04 Oct 2013 14:19

Last Modified:

23 Jan 2018 12:16

Publisher DOI:

10.1213/ANE.0b013e31821d01bc

PubMed ID:

21596874

Web of Science ID:

000291971900010

URI:

https://boris.unibe.ch/id/eprint/6115 (FactScience: 211015)

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