Correlation between disease severity and brain electric LORETA tomography in Alzheimer's disease

Gianotti, Lorena; Künig, Gabriella; Lehmann, Dietrich; Faber, Pascal L; Pascual-Marqui, Roberto D; Kochi, Kieko; Schreiter-Gasser, Ursula (2007). Correlation between disease severity and brain electric LORETA tomography in Alzheimer's disease. Clinical neurophysiology, 118(1), pp. 186-196. Elsevier 10.1016/j.clinph.2006.09.007

[img] Text
1-s2.0-S1388245706014398-main.pdf__tid=d1cb02e8-8b51-11e4-9561-00000aacb360&acdnat=1419414605_aefe69b3c02de8ea48772fcc680ce712 - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

OBJECTIVE To compare EEG power spectra and LORETA-computed intracortical activity between Alzheimer's disease (AD) patients and healthy controls, and to correlate the results with cognitive performance in the AD group. METHODS Nineteen channel resting EEG was recorded in 21 mild to moderate AD patients and in 23 controls. Power spectra and intracortical LORETA tomography were computed in seven frequency bands and compared between groups. In the AD patients, the EEG results were correlated with cognitive performance (Mini Mental State Examination, MMSE). RESULTS AD patients showed increased power in EEG delta and theta frequency bands, and decreased power in alpha2, beta1, beta2 and beta3. LORETA specified that increases and decreases of power affected different cortical areas while largely sparing prefrontal cortex. Delta power correlated negatively and alpha1 power positively with the AD patients' MMSE scores; LORETA tomography localized these correlations in left temporo-parietal cortex. CONCLUSIONS The non-invasive EEG method of LORETA localized pathological cortical activity in our mild to moderate AD patients in agreement with the literature, and yielded striking correlations between EEG delta and alpha1 activity and MMSE scores in left temporo-parietal cortex. SIGNIFICANCE The present data support the hypothesis of an asymmetrical progression of the Alzheimer's disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

07 Faculty of Human Sciences > Institute of Psychology > Social Psychology and Social Neuroscience

UniBE Contributor:

Gianotti, Lorena

Subjects:

100 Philosophy > 150 Psychology

ISSN:

1388-2457

Publisher:

Elsevier

Language:

English

Submitter:

Lorena Gianotti

Date Deposited:

24 Dec 2014 10:46

Last Modified:

27 Dec 2014 18:06

Publisher DOI:

10.1016/j.clinph.2006.09.007

PubMed ID:

17070733

Uncontrolled Keywords:

Alzheimer’s disease, EEG, Spectral analysis, EEG source localization, LORETA, Tomography

BORIS DOI:

10.7892/boris.61184

URI:

https://boris.unibe.ch/id/eprint/61184

Actions (login required)

Edit item Edit item
Provide Feedback