DAT1 polymorphism determines L-DOPA effects on learning about others' prosociality.

Eisenegger, Christoph; Pedroni, Andreas; Rieskamp, Jörg; Zehnder, Christian; Ebstein, Richard; Fehr, Ernst; Knoch, Daria (2013). DAT1 polymorphism determines L-DOPA effects on learning about others' prosociality. PLoS ONE, 8(7), e67820. Public Library of Science 10.1371/journal.pone.0067820

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Despite that a wealth of evidence links striatal dopamine to individualś reward learning performance in non-social environments, the neurochemical underpinnings of such learning during social interaction are unknown. Here, we show that the administration of 300 mg of the dopamine precursor L-DOPA to 200 healthy male subjects influences learning about a partners' prosocial preferences in a novel social interaction task, which is akin to a repeated trust game. We found learning to be modulated by a well-established genetic marker of striatal dopamine levels, the 40-bp variable number tandem repeats polymorphism of the dopamine transporter (DAT1 polymorphism). In particular, we found that L-DOPA improves learning in 10/10R genoype subjects, who are assumed to have lower endogenous striatal dopamine levels and impairs learning in 9/10R genotype subjects, who are assumed to have higher endogenous dopamine levels. These findings provide first evidence for a critical role of dopamine in learning whether an interaction partner has a prosocial or a selfish personality. The applied pharmacogenetic approach may open doors to new ways of studying psychiatric disorders such as psychosis, which is characterized by distorted perceptions of others' prosocial attitudes.

Item Type:

Journal Article (Original Article)

Division/Institute:

07 Faculty of Human Sciences > Institute of Psychology > Social Psychology and Social Neuroscience

UniBE Contributor:

Knoch, Daria

Subjects:

100 Philosophy > 150 Psychology

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Irène Gonce-Gyr

Date Deposited:

22 Dec 2014 11:35

Last Modified:

24 Dec 2014 02:01

Publisher DOI:

10.1371/journal.pone.0067820

PubMed ID:

23861813

BORIS DOI:

10.7892/boris.61194

URI:

https://boris.unibe.ch/id/eprint/61194

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