Knoch, Daria; Brugger, Peter; Regard, Marianne (2005). Suppressing versus releasing a habit: frequency-dependent effects of prefrontal transcranial magnetic stimulation. Cerebral cortex, 15(7), pp. 885-887. Oxford University Press 10.1093/cercor/bhh196
|
Text
bhh196.pdf - Published Version Available under License Publisher holds Copyright. Download (165kB) | Preview |
When subjects are required to generate a random sequence of numbers they typically produce too many forward and backward 'counts' (e.g. 5-6, 4-3). This counting bias is interpreted as the consequence of an interference by overlearned tendencies to arrange numbers according to their natural order. Inhibition of such well-learned routines is known to rely on frontal lobe functioning. We examined differential effects of slow (1 Hz) and fast (10 Hz) repetitive transcranial magnetic stimulation (rTMS) over the left or right dorsolateral prefrontal cortex (DLPFC) on random number generation (RNG) performance. Eighteen healthy men performed an RNG task. Those subjects stimulated over the left DLPFC showed a frequency-dependent rTMS effect: counting bias was significantly reduced after the 1 Hz stimulation compared with baseline, but significantly exaggerated after the 10 Hz stimulation compared with 1 Hz stimulation. In contrast, the sequences of the subjects stimulated over the right DLPFC showed the well-known excess of counting in all conditions (i.e. baseline, 1 Hz and 10 Hz). These findings confirm the functional importance of specifically the left DLPFC in sequential response production and show, for the first time, that rTMS affects cognitive processing in a frequency-dependent manner.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
07 Faculty of Human Sciences > Institute of Psychology > Social Neuroscience and Social Psychology |
UniBE Contributor: |
Knoch, Daria |
Subjects: |
100 Philosophy > 150 Psychology 300 Social sciences, sociology & anthropology |
ISSN: |
1047-3211 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Irène Gonce-Gyr |
Date Deposited: |
22 Dec 2014 13:50 |
Last Modified: |
05 Dec 2022 14:38 |
Publisher DOI: |
10.1093/cercor/bhh196 |
PubMed ID: |
15483046 |
BORIS DOI: |
10.48350/61206 |
URI: |
https://boris.unibe.ch/id/eprint/61206 |
Actions (login required)
 |
Edit item |