Suppressing versus releasing a habit: frequency-dependent effects of prefrontal transcranial magnetic stimulation.

Knoch, Daria; Brugger, Peter; Regard, Marianne (2005). Suppressing versus releasing a habit: frequency-dependent effects of prefrontal transcranial magnetic stimulation. Cerebral cortex, 15(7), pp. 885-887. Oxford University Press 10.1093/cercor/bhh196

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When subjects are required to generate a random sequence of numbers they typically produce too many forward and backward 'counts' (e.g. 5-6, 4-3). This counting bias is interpreted as the consequence of an interference by overlearned tendencies to arrange numbers according to their natural order. Inhibition of such well-learned routines is known to rely on frontal lobe functioning. We examined differential effects of slow (1 Hz) and fast (10 Hz) repetitive transcranial magnetic stimulation (rTMS) over the left or right dorsolateral prefrontal cortex (DLPFC) on random number generation (RNG) performance. Eighteen healthy men performed an RNG task. Those subjects stimulated over the left DLPFC showed a frequency-dependent rTMS effect: counting bias was significantly reduced after the 1 Hz stimulation compared with baseline, but significantly exaggerated after the 10 Hz stimulation compared with 1 Hz stimulation. In contrast, the sequences of the subjects stimulated over the right DLPFC showed the well-known excess of counting in all conditions (i.e. baseline, 1 Hz and 10 Hz). These findings confirm the functional importance of specifically the left DLPFC in sequential response production and show, for the first time, that rTMS affects cognitive processing in a frequency-dependent manner.

Item Type:

Journal Article (Original Article)

Division/Institute:

07 Faculty of Human Sciences > Institute of Psychology > Social Psychology and Social Neuroscience

UniBE Contributor:

Knoch, Daria

Subjects:

100 Philosophy > 150 Psychology
300 Social sciences, sociology & anthropology

ISSN:

1047-3211

Publisher:

Oxford University Press

Language:

English

Submitter:

Irène Gonce-Gyr

Date Deposited:

22 Dec 2014 13:50

Last Modified:

22 Dec 2014 13:50

Publisher DOI:

10.1093/cercor/bhh196

PubMed ID:

15483046

URI:

https://boris.unibe.ch/id/eprint/61206

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