Correlation between serum total globulins and gamma globulins and their use to diagnose failure of passive transfer in foals.

Fouché, Nathalie Elisa; Graubner, Claudia; Howard, J. (2014). Correlation between serum total globulins and gamma globulins and their use to diagnose failure of passive transfer in foals. Veterinary journal, 202(2), pp. 384-386. Elsevier 10.1016/j.tvjl.2014.08.013

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Various assays have been used as an aid to diagnose failure of passive transfer (FPT) of immunoglobulins in neonatal foals, but often lack sensitivity as screening tests, or are time consuming to perform and impractical as confirmatory tests. The aim of the present study was to evaluate whether measurement of serum total globulins (TG; i.e. total protein minus albumin) can be used to estimate the electrophoretic gamma globulin (EGG) fraction in hospitalised neonatal foals with suspected FPT. Sample data from 56 foals were evaluated retrospectively. The coefficient of rank correlation was 0.84. The area under the curve of ROC analysis was 0.887, 0.922 and 0.930 for EGG concentrations <2 g/L, < 4 g/L and <8 g/L, respectively. Cut-offs for TG achieved ≥90% sensitivity for detecting EGG <2 g/L, < 4 g/L and <8 g/L, with negative predictive values of >97% and >94%, using prevalence of 15% and 30%, respectively. These results suggest that measurement of TG can be used as a guide to predicting EGG, provided that appropriate cut-off values are selected, and this technique could be a useful initial screening test for FPT in foals.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Veterinary Public Health / Herd Health Management
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Central Clinical Laboratory

UniBE Contributor:

Fouché, Nathalie Elisa; Graubner, Claudia and Howard, Judith

Subjects:

600 Technology > 630 Agriculture

ISSN:

1090-0233

Publisher:

Elsevier

Language:

English

Submitter:

Andrea Gassmann-Suter

Date Deposited:

24 Dec 2014 11:57

Last Modified:

15 Oct 2015 08:53

Publisher DOI:

10.1016/j.tvjl.2014.08.013

PubMed ID:

25201248

Uncontrolled Keywords:

Globulins, Horse, Immunoglobulins, Serum electrophoresis, Total protein

BORIS DOI:

10.7892/boris.61300

URI:

https://boris.unibe.ch/id/eprint/61300

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