Fouché, Nathalie Elisa; Graubner, Claudia; Howard, J. (2014). Correlation between serum total globulins and gamma globulins and their use to diagnose failure of passive transfer in foals. Veterinary journal, 202(2), pp. 384-386. Elsevier 10.1016/j.tvjl.2014.08.013
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Correlation between serum total globulins and gamma globulins and their use to diagnose failure of passive transfer in foals.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (221kB) | Request a copy |
Various assays have been used as an aid to diagnose failure of passive transfer (FPT) of immunoglobulins in neonatal foals, but often lack sensitivity as screening tests, or are time consuming to perform and impractical as confirmatory tests. The aim of the present study was to evaluate whether measurement of serum total globulins (TG; i.e. total protein minus albumin) can be used to estimate the electrophoretic gamma globulin (EGG) fraction in hospitalised neonatal foals with suspected FPT. Sample data from 56 foals were evaluated retrospectively. The coefficient of rank correlation was 0.84. The area under the curve of ROC analysis was 0.887, 0.922 and 0.930 for EGG concentrations <2 g/L, < 4 g/L and <8 g/L, respectively. Cut-offs for TG achieved ≥90% sensitivity for detecting EGG <2 g/L, < 4 g/L and <8 g/L, with negative predictive values of >97% and >94%, using prevalence of 15% and 30%, respectively. These results suggest that measurement of TG can be used as a guide to predicting EGG, provided that appropriate cut-off values are selected, and this technique could be a useful initial screening test for FPT in foals.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Research Foci > Veterinary Public Health / Herd Health Management 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > ISME Equine Clinic Bern > ISME Equine Clinic, Internal medicine 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Central Clinical Laboratory |
UniBE Contributor: |
Fouché, Nathalie Elisa, Graubner, Claudia, Howard, Judith |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
1090-0233 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Andrea Gassmann-Suter |
Date Deposited: |
24 Dec 2014 11:57 |
Last Modified: |
05 Dec 2022 14:38 |
Publisher DOI: |
10.1016/j.tvjl.2014.08.013 |
PubMed ID: |
25201248 |
Uncontrolled Keywords: |
Globulins, Horse, Immunoglobulins, Serum electrophoresis, Total protein |
BORIS DOI: |
10.7892/boris.61300 |
URI: |
https://boris.unibe.ch/id/eprint/61300 |
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