Preliminary study on carprofen concentration measurements after transcutaneous treatment with Vetdrop® in a microfracture joint defect model in sheep.

Sidler, Michèle; Fouché, Nathalie Elisa; Meth, Ingmar; von Hahn, Friedrich; Von Rechenberg, Brigitte; Kronen, Peter W. (2014). Preliminary study on carprofen concentration measurements after transcutaneous treatment with Vetdrop® in a microfracture joint defect model in sheep. BMC veterinary research, 10(1), p. 268. BioMed Central 10.1186/s12917-014-0268-6

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BackgroundThe present preliminary study describes concentration time courses of the NSAID carprofen in the plasma and synovial fluid in a microfrature sheep model after transcutaneous treatments with a novel application device (Vetdrop®). To treat circumscribed inflammatory processes a transcutaneous application device could potentially be beneficial. After transcutaneous application normally lower systemic concentrations are measured which may reduce the incidence of side effects, whereas efficacy is still maintained.In this study carprofen was used based on its capacity to provide analgesia after orthopaedic procedures in sheep and it is considered that it may have a positive influence on the healing of cartilage in low concentrations.ResultsIn all transcutaneously treated animals, carprofen plasma concentrations exceeded those of synovial fluid, although plasma levels remained significantly reduced (300-fold) as compared to carprofen administered intravenously. Furthermore, in contrast to the intravenously treated animals, a modest accumulation of carprofen in plasma and synovial fluid was observed in the transcutaneously treated animals over the 6-week treatment period.ConclusionsThe transcutaneously administered carprofen using the Vetdrop® device penetrated the skin and both, plasma- and synovial concentrations could be measured repeatedly over time. This novel device may be considered a valuable transcutaneous drug delivery system.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)

UniBE Contributor:

Fouché, Nathalie Elisa and Von rechenberg, Brigitte

Subjects:

600 Technology > 630 Agriculture

ISSN:

1746-6148

Publisher:

BioMed Central

Language:

English

Submitter:

Andrea Gassmann-Suter

Date Deposited:

24 Dec 2014 12:23

Last Modified:

18 Feb 2015 12:42

Publisher DOI:

10.1186/s12917-014-0268-6

PubMed ID:

25488522

Uncontrolled Keywords:

Carprofen concentration measurements, Transcutaneous treatment, Sheep

BORIS DOI:

10.7892/boris.61303

URI:

https://boris.unibe.ch/id/eprint/61303

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