Ultrastructural mitochondrial alterations in Equine myopathies of unknown origin.

Van Driessche, K; Ducatelle, R; Chiers, K; Van Coster, R; van der Kolk, Johannes Hermanus (2015). Ultrastructural mitochondrial alterations in Equine myopathies of unknown origin. Veterinary quarterly, 35(1), pp. 2-8. Taylor & Francis 10.1080/01652176.2015.983681

[img] Text
Ultrastructural mitochondrial alterations in Equine myopathies of unknown origin.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (658kB) | Request a copy

Background: Very few mitochondrial myopathies have been described in horses. Objective: To examine the ultrastructure of muscle mitochondria in equine cases of myopathy of unknown origin. Materials & methods: Biopsies of vastus lateralis of the Musculus quadriceps femoris were taken predominantly immediately post mortem and processed for transmission electron microscopy. As a result, electron micrographs of 90 horses in total were available for analysis comprising 4 control horses, 16 horses suffering from myopathy and 70 otherwise diseased horses. Results: Following a thorough clinical and laboratory work-up, four out of five patients that did not fit into the usual algorithm to detect known causes of myopathy showed ultrastructural mitochondrial alterations. Small mitochondria with zones with complete disruption of cristae associated with lactic acidemia were detected in a 17-year-old pony mare, extremely long and slender mitochondria with longitudinal cristae in a 5-year-old Quarter horse stallion, a mixture of irregular extremely large mitochondria (measuring 2500 by 800 nm) next to smaller ones in an 8-year-old Hanoverian mare and round mitochondria with only few cristae in a 11-year-old pony gelding. It remains uncertain whether the subsarcolemmal mitochondrial accumulations observed in the fifth patient have any pathological significance. Conclusions: Ultrastructural alterations in mitochondria were detected in at least four horses. To conclude that these are due to mitochondrial dysfuntions, biochemical tests should be performed. Practical applications: The possibility of a mitochondrial myopathy should be included in the differential diagnosis of muscle weakness.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)

UniBE Contributor:

van der Kolk, Johannes Hermanus

Subjects:

600 Technology > 630 Agriculture

ISSN:

0165-2176

Publisher:

Taylor & Francis

Language:

English

Submitter:

Andrea Gassmann-Suter

Date Deposited:

29 Dec 2014 15:32

Last Modified:

15 Oct 2015 08:53

Publisher DOI:

10.1080/01652176.2015.983681

PubMed ID:

25365353

Uncontrolled Keywords:

Musculus quadriceps femoris, equine, horse, mitochondrion, myopathy, ultrastructure

BORIS DOI:

10.7892/boris.61318

URI:

https://boris.unibe.ch/id/eprint/61318

Actions (login required)

Edit item Edit item
Provide Feedback