Tappeiner, Christoph; Tschopp, Markus; Schürch, Kaspar Werner; Früh Epstein, Beatrice (2014). Impact of corneal cross-linking on topical drug penetration in humans. Acta ophthalmologica, 93(5), e324-e327. Blackwell Munksgaard 10.1111/aos.12595
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PURPOSE
To analyse the influence of corneal cross-linking (CXL) with ultraviolet-A (UV-A) and riboflavin on drug permeability in human subjects.
METHODS
Keratoconus patients (n = 23; mean age 26.9 ± 5.8 years) undergoing a standard CXL procedure with UV-A (5.4 J/cm(2) , 30 min) and riboflavin in one eye were included in the study. The pupillary diameter, measured before and every 3 min for 30 min after the topical application of one drop of 2% pilocarpine, was used as an indirect measure of the corneal permeability. The pupillary diameter was measured with an infrared pupillometer device before (baseline) and 4 months after CXL.
RESULTS
Prior to pilocarpine application, no significant difference in the pupillary diameter was detected before CXL and 4 months later. The mean decrease in the pupillary diameter after the application of pilocarpine was similar at baseline and the 4-month follow-up visit: mean decreases of 3.9 and 3.7 mm were observed 30 min after pilocarpine application, respectively (p > 0.05).
CONCLUSIONS
No significant influence of CXL on the corneal penetration of topically applied pilocarpine was observed in this clinical study.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Tappeiner, Christoph, Tschopp, Markus, Schürch, Kaspar Werner, Früh Epstein, Beatrice |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1755-375X |
Publisher: |
Blackwell Munksgaard |
Language: |
English |
Submitter: |
Christoph Tappeiner |
Date Deposited: |
06 Jan 2015 13:55 |
Last Modified: |
05 Dec 2022 14:38 |
Publisher DOI: |
10.1111/aos.12595 |
PubMed ID: |
25402571 |
Uncontrolled Keywords: |
in vivo, cornea, corneal cross-linking, drug penetration, keratoconus, pilocarpine, pupillometry |
BORIS DOI: |
10.7892/boris.61493 |
URI: |
https://boris.unibe.ch/id/eprint/61493 |
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