Impact of corneal cross-linking on topical drug penetration in humans.

Tappeiner, Christoph; Tschopp, Markus; Schürch, Kaspar Werner; Früh Epstein, Beatrice (2014). Impact of corneal cross-linking on topical drug penetration in humans. Acta ophthalmologica, 93(5), e324-e327. Blackwell Munksgaard 10.1111/aos.12595

[img] Text
aos12595.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (184kB) | Request a copy

PURPOSE

To analyse the influence of corneal cross-linking (CXL) with ultraviolet-A (UV-A) and riboflavin on drug permeability in human subjects.

METHODS

Keratoconus patients (n = 23; mean age 26.9 ± 5.8 years) undergoing a standard CXL procedure with UV-A (5.4 J/cm(2) , 30 min) and riboflavin in one eye were included in the study. The pupillary diameter, measured before and every 3 min for 30 min after the topical application of one drop of 2% pilocarpine, was used as an indirect measure of the corneal permeability. The pupillary diameter was measured with an infrared pupillometer device before (baseline) and 4 months after CXL.

RESULTS

Prior to pilocarpine application, no significant difference in the pupillary diameter was detected before CXL and 4 months later. The mean decrease in the pupillary diameter after the application of pilocarpine was similar at baseline and the 4-month follow-up visit: mean decreases of 3.9 and 3.7 mm were observed 30 min after pilocarpine application, respectively (p > 0.05).

CONCLUSIONS

No significant influence of CXL on the corneal penetration of topically applied pilocarpine was observed in this clinical study.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Tappeiner, Christoph; Tschopp, Markus; Schürch, Kaspar Werner and Früh Epstein, Beatrice

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1755-375X

Publisher:

Blackwell Munksgaard

Language:

English

Submitter:

Christoph Tappeiner

Date Deposited:

06 Jan 2015 13:55

Last Modified:

28 Nov 2020 02:25

Publisher DOI:

10.1111/aos.12595

PubMed ID:

25402571

Uncontrolled Keywords:

in vivo, cornea, corneal cross-linking, drug penetration, keratoconus, pilocarpine, pupillometry

BORIS DOI:

10.7892/boris.61493

URI:

https://boris.unibe.ch/id/eprint/61493

Actions (login required)

Edit item Edit item
Provide Feedback