Evaluation of a new experimental model to study bone healing after ridge expansion with simultaneous implant placement--a pilot study in minipigs.

Stricker, Andres; Fleiner, Jonathan; Dard, Michel; Voss, Pit; Sauerbier, Sebastian; Bosshardt, Dieter (2014). Evaluation of a new experimental model to study bone healing after ridge expansion with simultaneous implant placement--a pilot study in minipigs. Clinical oral implants research, 25(11), pp. 1265-1272. Wiley-Blackwell 10.1111/clr.12265

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OBJECTIVE To evaluate the suitability of a minipig model for the study of bone healing and osseointegration of dental implants following bone splitting and expansion of narrow ridges. MATERIAL AND METHODS In four minipigs, the mandibular premolars and first molars were extracted together with removal of the buccal bone plate. Three months later, ridge splitting and expansion was performed with simultaneous placement of three titanium implants per quadrant. On one side of the mandible, the expanded bone gap between the implants was filled with an alloplastic biphasic calcium phosphate (BCP) material, while the gap on the other side was left unfilled. A barrier membrane was placed in half of the quadrants. After a healing period of 6 weeks, the animals were sacrificed for histological evaluation. RESULTS In all groups, no bone fractures occurred, no implants were lost, all 24 implants were osseointegrated, and the gap created by bone splitting was filled with new bone, irrespective of whether BCP or a barrier membrane was used. Slight exposure of five implants was observed, but did not lead to implant loss. The level of the most coronal bone-to-implant contact varied without being dependent on the use of BCP or a barrier membrane. In all groups, the BCP particles were not present deep in the bone-filled gap. However, BCP particles were seen at the crestal bone margin, where they were partly integrated in the new bone. CONCLUSIONS This new minipig model holds great promise for studying experimental ridge splitting/expansion. However, efforts must be undertaken to reduce implant exposure and buccal bone resorption.

Item Type:

Journal Article (Original Article)

UniBE Contributor:

Bosshardt, Dieter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0905-7161

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

09 Jan 2015 10:52

Last Modified:

25 Jan 2017 12:15

Publisher DOI:

10.1111/clr.12265

PubMed ID:

24102886

Uncontrolled Keywords:

biphasic bone substitute, bone regeneration, bone splitting/ridge expansion, minipig, osseointegration

BORIS DOI:

10.7892/boris.61499

URI:

https://boris.unibe.ch/id/eprint/61499

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