Noninvasive referencing of intraocular tumors for external beam radiation therapy using optical coherence tomography: a proof of concept.

Rüegsegger, Michael B; Geiser, Dominik; Steiner, Patrick; Pica, Alessia; Aebersold, Daniel; Kowal, Jens H (2014). Noninvasive referencing of intraocular tumors for external beam radiation therapy using optical coherence tomography: a proof of concept. Medical physics, 41(8), 081704. American Association of Physicists in Medicine AAPM 10.1118/1.4885975

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PURPOSE External beam radiation therapy is currently considered the most common treatment modality for intraocular tumors. Localization of the tumor and efficient compensation of tumor misalignment with respect to the radiation beam are crucial. According to the state of the art procedure, localization of the target volume is indirectly performed by the invasive surgical implantation of radiopaque clips or is limited to positioning the head using stereoscopic radiographies. This work represents a proof-of-concept for direct and noninvasive tumor referencing based on anterior eye topography acquired using optical coherence tomography (OCT). METHODS A prototype of a head-mounted device has been developed for automatic monitoring of tumor position and orientation in the isocentric reference frame for LINAC based treatment of intraocular tumors. Noninvasive tumor referencing is performed with six degrees of freedom based on anterior eye topography acquired using OCT and registration of a statistical eye model. The proposed prototype was tested based on enucleated pig eyes and registration accuracy was measured by comparison of the resulting transformation with tilt and torsion angles manually induced using a custom-made test bench. RESULTS Validation based on 12 enucleated pig eyes revealed an overall average registration error of 0.26 ± 0.08° in 87 ± 0.7 ms for tilting and 0.52 ± 0.03° in 94 ± 1.4 ms for torsion. Furthermore, dependency of sampling density on mean registration error was quantitatively assessed. CONCLUSIONS The tumor referencing method presented in combination with the statistical eye model introduced in the past has the potential to enable noninvasive treatment and may improve quality, efficacy, and flexibility of external beam radiotherapy of intraocular tumors.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Steiner, Patrick; Pica, Alessia and Aebersold, Daniel

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0094-2405

Publisher:

American Association of Physicists in Medicine AAPM

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

10 Mar 2015 15:27

Last Modified:

09 Nov 2015 10:03

Publisher DOI:

10.1118/1.4885975

PubMed ID:

25086514

BORIS DOI:

10.7892/boris.61601

URI:

https://boris.unibe.ch/id/eprint/61601

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