Valko, Philipp O; Siddique, Asim; Linsenmeier, Claudia; Zaugg, Kathrin; Held, Ulrike; Hofer, Silvia (2015). Prevalence and predictors of fatigue in glioblastoma: a prospective study. Neuro-Oncology, 17(2), pp. 274-281. Oxford University Press 10.1093/neuonc/nou127
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BACKGROUND
The main goal of this study was to assess frequency, clinical correlates, and independent predictors of fatigue in a homogeneous cohort of well-defined glioblastoma patients at baseline prior to combined radio-chemotherapy.
METHODS
We prospectively included 65 glioblastoma patients at postsurgical baseline and assessed fatigue, sleepiness, mean bedtimes, mood disturbances, and clinical characteristics such as clinical performance status, presenting symptomatology, details on neurosurgical procedure, and tumor location and diameter as well as pharmacological treatment including antiepileptic drugs, antidepressants, and use of corticosteroids. Data on fatigue and sleepiness were measured with the Fatigue Severity Scale and the Epworth Sleepiness Scale, respectively, and compared with 130 age- and sex-matched healthy controls.
RESULTS
We observed a significant correlation between fatigue and sleepiness scores in both patients (r = 0.26; P = .04) and controls (r = 0.36; P < .001). Only fatigue appeared to be more common in glioblastoma patients than in healthy controls (48% vs 11%; P < .001) but not the frequency of sleepiness (22% vs 19%; P = .43). Female sex was associated with increased fatigue frequency among glioblastoma patients but not among control participants. Multiple linear regression analyses identified depression, left-sided tumor location, and female sex as strongest associates of baseline fatigue severity.
CONCLUSIONS
Our findings indicate that glioblastoma patients are frequently affected by fatigue at baseline, suggesting that factors other than those related to radio- or chemotherapy have significant impact, particularly depression and tumor localization.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology |
UniBE Contributor: |
Zaugg, Kathrin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1523-5866 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Beatrice Scheidegger |
Date Deposited: |
10 Mar 2015 16:29 |
Last Modified: |
05 Dec 2022 14:39 |
Publisher DOI: |
10.1093/neuonc/nou127 |
PubMed ID: |
25006033 |
Uncontrolled Keywords: |
depression, fatigue, glioblastoma, sleepiness |
BORIS DOI: |
10.7892/boris.61606 |
URI: |
https://boris.unibe.ch/id/eprint/61606 |
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