Relationship between survival and increased radiation dose to subventricular zone in glioblastoma is controversial.

Eliçin, Olgun; Inac, Ebrar; Uzel, Esengul Kocak; Karacam, Songul; Uzel, Omer Erol (2014). Relationship between survival and increased radiation dose to subventricular zone in glioblastoma is controversial. Journal of neuro-oncology, 118(2), pp. 413-419. Springer 10.1007/s11060-014-1424-3

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To test the hypothesis on prolonged survival in glioblastoma cases with increased subventricular zone (SVZ) radiation dose. Sixty glioblastoma cases were previously treated with adjuvant radiotherapy and Temozolamide. Ipsilateral, contralateral and bilateral SVZs were contoured and their doses were retrospectively evaluated. Median follow-up, progression free survival (PFS) and overall survival (OS) were 24.5, 8.5 and 19.3 months respectively. Log-rank tests showed a statistically significant correlation between contralateral SVZ (cSVZ) dose > 59.2 Gy (75th percentile) and poor median PFS (10.37 [95% CI 8.37-13.53] vs 7.1 [95% CI 3.5-8.97] months, p = 0.009). cSVZ dose > 59.2 Gy was associated with poor OS in the subgroup with subtotal resection/biopsy (HR: 4.83 [95% CI 1.71-13.97], p = 0.004). High ipsilateral SVZ dose of > 62.25 Gy (75th percentile) was associated with poor PFS in both subgroups of high performance status (HR: 2.58 [95% CI 1.03-6.05], p = 0.044) and SVZ without tumoral contact (HR: 10.57 [95% CI 2.04-49], p = 0.008). The effect of high cSVZ dose on PFS lost its statistical significance in multivariate Cox regression analysis. We report contradictory results compared to previous publications. Changing the clinical practice based on retrospective studies which even do not indicate consistent results among each other will be dangerous. We need carefully designed prospective randomized studies to evaluate any impact of radiation to SVZ in glioblastoma.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Eliçin, Olgun

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0167-594X

Publisher:

Springer

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

11 Mar 2015 15:32

Last Modified:

11 Apr 2017 09:45

Publisher DOI:

10.1007/s11060-014-1424-3

PubMed ID:

24668610

BORIS DOI:

10.7892/boris.61614

URI:

https://boris.unibe.ch/id/eprint/61614

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