Periodontal pathogens and associated factors in aggressive periodontitis: results 5-17 years after active periodontal therapy

Meyer-Bäumer, Amelie; Eick, Sigrun; Mertens, Christian; Uhlmann, Lorenz; Hagenfeld, Daniel; Eickholz, Peter; Kim, Ti-Sun; Cosgarea, Raluca (2014). Periodontal pathogens and associated factors in aggressive periodontitis: results 5-17 years after active periodontal therapy. Journal of clinical periodontology, 41(7), pp. 662-672. Wiley 10.1111/jcpe.12255

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OBJECTIVES To assess the association between presence of periodontal pathogens and recurrence of disease in patients with aggressive periodontitis (AgP) after active periodontal therapy (APT) and further influencing factors. MATERIAL & METHODS Microbiological samples were taken from 73 patients with AgP 5-17 years after APT at 292 sites (deepest site per quadrant). Real-time polymerase chain reactions were used to detect the periodontal pathogens Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola. Uni- and multivariate analyses evaluated the associations between pathogens and recurrence of disease, smoking and adjunctive antibiotic therapy. RESULTS At re-examination A. actinomycetemcomitans could be detected in six patients (8.2%), P. gingivalis in 24 (32.9%), T. forsythia in 31 (42.5%) and T. denticola in 35 (48.0%). Increased levels of T. forsythia and T. denticola at re-examination were significantly associated with recurrence of disease in multivariate analyses (OR: 12.72, p < 0.001; OR 5.55, p = 0.002 respectively). Furthermore, high counts of T. denticola were found in patients with increased percentage of sites with clinical attachment levels (CAL) ≥ 6 mm compared to those with low counts (13.8% versus 3.2%, p = 0.005). CONCLUSION In patients with recurrence of disease T. forsythia and T. denticola were detected more frequently and in higher counts. Furthermore, T. denticola was found more frequently in patients with increased CAL.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Eick, Sigrun

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0303-6979

Publisher:

Wiley

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

19 Jan 2015 16:06

Last Modified:

25 Jan 2017 12:15

Publisher DOI:

10.1111/jcpe.12255

PubMed ID:

24708362

Uncontrolled Keywords:

Aggregatibacter actinomycetemcomitans, Aggressive periodontitis, adjunctive antibiotic therapy, periodontal pathogens, recurrence of disease

BORIS DOI:

10.7892/boris.61669

URI:

https://boris.unibe.ch/id/eprint/61669

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