Crevicular fluid biomarkers and periodontal disease progression.

Kinney, Janet S; Morelli, Thiago; Oh, Min; Braun, Thomas M; Ramseier, Christoph Andreas; Sugai, Jim V; Giannobile, William V (2014). Crevicular fluid biomarkers and periodontal disease progression. Journal of clinical periodontology, 41(2), pp. 113-120. Wiley 10.1111/jcpe.12194

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AIM

Assess the ability of a panel of gingival crevicular fluid (GCF) biomarkers as predictors of periodontal disease progression (PDP).

MATERIALS AND METHODS

In this study, 100 individuals participated in a 12-month longitudinal investigation and were categorized into four groups according to their periodontal status. GCF, clinical parameters and saliva were collected bi-monthly. Subgingival plaque and serum were collected bi-annually. For 6 months, no periodontal treatment was provided. At 6 months, patients received periodontal therapy and continued participation from 6 to 12 months. GCF samples were analysed by ELISA for MMP-8, MMP-9, Osteoprotegerin, C-reactive Protein and IL-1β. Differences in median levels of GCF biomarkers were compared between stable and progressing participants using Wilcoxon Rank Sum test (p = 0.05). Clustering algorithm was used to evaluate the ability of oral biomarkers to classify patients as either stable or progressing.

RESULTS

Eighty-three individuals completed the 6-month monitoring phase. With the exception of GCF C-reactive protein, all biomarkers were significantly higher in the PDP group compared to stable patients. Clustering analysis showed highest sensitivity levels when biofilm pathogens and GCF biomarkers were combined with clinical measures, 74% (95% CI = 61, 86).

CONCLUSIONS

Signature of GCF fluid-derived biomarkers combined with pathogens and clinical measures provides a sensitive measure for discrimination of PDP (ClinicalTrials.gov NCT00277745).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Ramseier, Christoph Andreas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0303-6979

Publisher:

Wiley

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

15 Jan 2015 09:29

Last Modified:

25 Jan 2017 12:15

Publisher DOI:

10.1111/jcpe.12194

PubMed ID:

24303954

Uncontrolled Keywords:

biomarkers, disease progression, gingival crevicular fluid, longitudinal, periodontitis

BORIS DOI:

10.7892/boris.61682

URI:

https://boris.unibe.ch/id/eprint/61682

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