Combined aerobic/inspiratory muscle training vs. aerobic training in patients with chronic heart failure: The Vent-HeFT trial: a European prospective multicentre randomized trial

Adamopoulos, Stamatis; Schmid, Jean-Paul; Dendale, Paul; Poerschke, Daniel; Hansen, Dominique; Dritsas, Athanasios; Kouloubinis, Alexandros; Alders, Toon; Gkouziouta, Aggeliki; Reyckers, Ilse; Vartela, Vasiliki; Plessas, Nikos; Doulaptsis, Costas; Saner, Hugo; Laoutaris, Ioannis D (2014). Combined aerobic/inspiratory muscle training vs. aerobic training in patients with chronic heart failure: The Vent-HeFT trial: a European prospective multicentre randomized trial. European journal of heart failure, 16(5), pp. 574-582. Oxford University Press 10.1002/ejhf.70

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AIMS Vent-HeFT is a multicentre randomized trial designed to investigate the potential additive benefits of inspiratory muscle training (IMT) on aerobic training (AT) in patients with chronic heart failure (CHF). METHODS AND RESULTS Forty-three CHF patients with a mean age of 58 ± 12 years, peak oxygen consumption (peak VO2 ) 17.9 ± 5 mL/kg/min, and LVEF 29.5 ± 5% were randomized to an AT/IMT group (n = 21) or to an AT/SHAM group (n = 22) in a 12-week exercise programme. AT involved 45 min of ergometer training at 70-80% of maximum heart rate, three times a week for both groups. In the AT/IMT group, IMT was performed at 60% of sustained maximal inspiratory pressure (SPImax ) while in the AT/SHAM group it was performed at 10% of SPImax , using a computer biofeedback trainer for 30 min, three times a week. At baseline and at 3 months, patients were evaluated for exercise capacity, lung function, inspiratory muscle strength (PImax ) and work capacity (SPImax ), quality of life (QoL), LVEF and LV diameter, dyspnoea, C-reactive protein (CRP), and NT-proBNP. IMT resulted in a significantly higher benefit in SPImax (P = 0.02), QoL (P = 0.002), dyspnoea (P = 0.004), CRP (P = 0.03), and NT-proBNP (P = 0.004). In both AT/IMT and AT/SHAM groups PImax (P < 0.001, P = 0.02), peak VO2 (P = 0.008, P = 0.04), and LVEF (P = 0.005, P = 0.002) improved significantly; however, without an additional benefit for either of the groups. CONCLUSION This randomized multicentre study demonstrates that IMT combined with aerobic training provides additional benefits in functional and serum biomarkers in patients with moderate CHF. These findings advocate for application of IMT in cardiac rehabilitation programmes.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Schmid, Jean-Paul and Saner, Hugo

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1388-9842

Publisher:

Oxford University Press

Language:

English

Submitter:

David Herzig

Date Deposited:

23 Jan 2015 15:54

Last Modified:

28 Oct 2015 11:28

Publisher DOI:

10.1002/ejhf.70

PubMed ID:

24634346

Uncontrolled Keywords:

Aerobic training Chronic heart failure Exercise Inspiratory muscle training Quality of life Rehabilitation Vent-HeFT trial

BORIS DOI:

10.7892/boris.61878

URI:

https://boris.unibe.ch/id/eprint/61878

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