Developing Psychosis and Its Risk States Through the Lens of Schizotypy

Debbané, Martin; Eliez, Stephan; Badoud, Deborah; Conus, Philippe; Flückiger, Rahel; Schultze-Lutter, Frauke (2015). Developing Psychosis and Its Risk States Through the Lens of Schizotypy. Schizophrenia bulletin, 41(suppl 2), S396-S407. Oxford University Press 10.1093/schbul/sbu176

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Starting from the early descriptions of Kraepelin and Bleuler, the construct of schizotypy was developed from observations of aberrations in nonpsychotic family members of schizophrenia patients. In contemporary diagnostic manuals, the positive symptoms of schizotypal personality disorder were included in the ultra high-risk (UHR) criteria 20 years ago, and nowadays are broadly employed in clinical early detection of psychosis. The schizotypy construct, now dissociated from strict familial risk, also informed research on the liability to develop any psychotic disorder, and in particular schizophrenia-spectrum disorders, even outside clinical settings. Against the historical background of schizotypy it is surprising that evidence from longitudinal studies linking schizotypy, UHR, and conversion to psychosis has only recently emerged; and it still remains unclear how schizotypy may be positioned in high-risk research. Following a comprehensive literature search, we review 18 prospective studies on 15 samples examining the evidence for a link between trait schizotypy and conversion to psychosis in 4 different types of samples: general population, clinical risk samples according to UHR and/or basic symptom criteria, genetic (familial) risk, and clinical samples at-risk for a nonpsychotic schizophrenia-spectrum diagnosis. These prospective studies underline the value of schizotypy in high-risk research, but also point to the lack of evidence needed to better define the position of the construct of schizotypy within a developmental psychopathology perspective of emerging psychosis and schizophrenia-spectrum disorders

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division

UniBE Contributor:

Flückiger, Rahel and Schultze-Lutter, Frauke

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0586-7614

Publisher:

Oxford University Press

Language:

English

Submitter:

Nicole Jansen

Date Deposited:

27 Jan 2015 10:27

Last Modified:

28 Apr 2018 02:30

Publisher DOI:

10.1093/schbul/sbu176

PubMed ID:

25548386

Uncontrolled Keywords:

adolescence, basic symptoms, development, prodrome, schizophrenia

BORIS DOI:

10.7892/boris.62102

URI:

https://boris.unibe.ch/id/eprint/62102

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