Clinical results with the Resolute zotarolimus-eluting stent in total coronary occlusions.

Kelbæk, Henning; Holmvang, Lene; Richardt, Gert; Eberli, Franz R; Stella, Pieter; Buszman, Pawel E; Neumann, Franz-Josef; Serruys, Patrick W; Windecker, Stephan; Widimský, Petr; Belardi, Jorge A; Silber, Sigmund (2015). Clinical results with the Resolute zotarolimus-eluting stent in total coronary occlusions. EuroIntervention, 11(6), pp. 650-657. Europa Digital & Publishing 10.4244/EIJY14M07_14

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Aims: We conducted a pooled post hoc analysis (RESOLUTE All Comers and RESOLUTE International) of patients who had the Resolute® zotarolimus-eluting stent (R-ZES) implanted in revascularised total occlusions (TO) compared with patients treated with R-ZES for non-occluded lesions. Methods and results: Patients were divided into three groups: chronic TO (CTO; n=256), non-chronic TO (n=292), and no occlusion (n=2,941). Clinical and safety outcomes assessed through two years included target lesion failure (TLF: cardiac death, target vessel myocardial infarction, and clinically driven target lesion revascularisation) and Academic Research Consortium definite or probable stent thrombosis. The rate of TLF at two years was not significantly different among patients in the CTO (9.1%), TO (9.8%), and no occlusion (10.4%) groups (log-rank p=0.800); neither were the components of TLF. Definite or probable stent thrombosis occurred more frequently in the TO group (2.8% vs. 1.2% in the CTO and 1.1% in the group with no occlusion, p=0.027). There were 10 late and six very late stent thrombosis events. Conclusions: Apart from a higher rate of stent thrombosis in patients with TO, patients with totally occluded coronary arteries who receive revascularisation with an R-ZES have clinical outcomes comparable to those who receive a similar stent in non-occluded lesions.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Windecker, Stephan


600 Technology > 610 Medicine & health




Europa Digital & Publishing




Judith Liniger

Date Deposited:

09 Feb 2015 15:38

Last Modified:

28 Oct 2015 01:30

Publisher DOI:


PubMed ID:



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