Temporal evolution of strut light intensity after implantation of bioresorbable polymeric intracoronary scaffolds in the ABSORB cohort B trial-an application of a new quantitative method based on optical coherence tomography.

Nakatani, Shimpei; Onuma, Yoshinobu; Ishibashi, Yuki; Eggermont, Jeroen; Zhang, Yao-Jun; Campos, Carlos M; Cho, Yun Kyeong; Liu, Shengnan; Dijkstra, Jouke; Reiber, Johan H C; Perkins, Laura; Sheehy, Alexander; Veldhof, Susan; Rapoza, Richard; van Es, Gerrit-Anne; Garcia-Garcia, Hector M; van Geuns, Robert-Jan; Serruys, Patrick W; Windecker, Stephan (2014). Temporal evolution of strut light intensity after implantation of bioresorbable polymeric intracoronary scaffolds in the ABSORB cohort B trial-an application of a new quantitative method based on optical coherence tomography. Circulation journal, 78(8), pp. 1873-1881. Japanese Circulation Society 10.1253/circj.CJ-14-0143

[img] Text
_pdf.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (3MB) | Request a copy

BACKGROUND Quantitative light intensity analysis of the strut core by optical coherence tomography (OCT) may enable assessment of changes in the light reflectivity of the bioresorbable polymeric scaffold from polymer to provisional matrix and connective tissues, with full disappearance and integration of the scaffold into the vessel wall. The aim of this report was to describe the methodology and to apply it to serial human OCT images post procedure and at 6, 12, 24 and 36 months in the ABSORB cohort B trial. METHODS AND RESULTS In serial frequency-domain OCT pullbacks, corresponding struts at different time points were identified by 3-dimensional foldout view. The peak and median values of light intensity were measured in the strut core by dedicated software. A total of 303 corresponding struts were serially analyzed at 3 time points. In the sequential analysis, peak light intensity increased gradually in the first 24 months after implantation and reached a plateau (relative difference with respect to baseline [%Dif]: 61.4% at 12 months, 115.0% at 24 months, 110.7% at 36 months), while the median intensity kept increasing at 36 months (%Dif: 14.3% at 12 months, 75.0% at 24 months, 93.1% at 36 months). CONCLUSIONS Quantitative light intensity analysis by OCT was capable of detecting subtle changes in the bioresorbable strut appearance over time, and could be used to monitor the bioresorption and integration process of polylactide struts.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Windecker, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1346-9843

Publisher:

Japanese Circulation Society

Language:

English

Submitter:

Judith Liniger

Date Deposited:

05 May 2015 16:28

Last Modified:

05 May 2015 16:28

Publisher DOI:

10.1253/circj.CJ-14-0143

PubMed ID:

24942012

BORIS DOI:

10.7892/boris.62120

URI:

https://boris.unibe.ch/id/eprint/62120

Actions (login required)

Edit item Edit item
Provide Feedback