Performance of the resolute zotarolimus-eluting stent in small vessels.

Caputo, Ronald; Leon, Martin; Serruys, Patrick; Neumann, Franz-Josef; Yeung, Alan; Windecker, Stephan; Belardi, Jorge A; Silber, Sigmund; Meredith, Ian; Widimský, Petr; Saito, Shigeru; Mauri, Laura (2014). Performance of the resolute zotarolimus-eluting stent in small vessels. Catheterization and cardiovascular interventions, 84(1), pp. 17-23. Wiley-Blackwell 10.1002/ccd.25485

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BACKGROUND Drug eluting stents for the treatment of small vessel coronary artery disease have traditionally yielded inferior clinical outcomes compared to the use of DES in large vessels. The benefit of the second-generation Resolute zotarolimus-eluting stent (R-ZES) in small vessels was examined. METHODS Two-year clinical outcomes from five combined R-ZES studies were compared between patients with small (reference vessel diameter [RVD] ≤2.5 mm; n = 1,956) and large (RVD >2.5 mm; n = 3174) vessels. RESULTS Despite a higher incidence of comorbidities in the small vessel group, there was no significant difference in target lesion failure (TLF) (10.1% vs. 8.7%; P = 0.54) at 2 years. When the subgroup of patients with diabetes was examined (n = 1,553) there was no significant difference in 2-year TLF in small compared to large vessels (11.2% vs. 11.1%; P = 0.17). Similarly, within the small vessel cohort, no significant difference was seen regarding TLF at 2 years between people with and without diabetes (11.2% vs 9.6%; P = 0.28). CONCLUSION When used for the treatment of small vessels, the R-ZES appears to provide acceptable clinical results at 2 years when compared to its performance in large vessels.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Windecker, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1522-1946

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Judith Liniger

Date Deposited:

05 Feb 2015 10:18

Last Modified:

28 Oct 2015 11:44

Publisher DOI:

10.1002/ccd.25485

PubMed ID:

24659581

Uncontrolled Keywords:

coronary artery disease, diabetes, drug eluting stent, small vessel disease

BORIS DOI:

10.7892/boris.62132

URI:

https://boris.unibe.ch/id/eprint/62132

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