Effect of different breathing AIDS on ventilation distribution in adults with cystic fibrosis.

Wettstein, Markus; Radlinger, Lorenz; Riedel, Thomas (2014). Effect of different breathing AIDS on ventilation distribution in adults with cystic fibrosis. PLoS ONE, 9(9), e106591. Public Library of Science 10.1371/journal.pone.0106591

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BACKGROUND AND OBJECTIVES

We investigated the effect of different breathing aids on ventilation distribution in healthy adults and subjects with cystic fibrosis (CF).

METHODS

In 11 healthy adults and 9 adults with CF electrical impedance tomography measurements were performed during spontaneous breathing, continuous positive airway pressure (CPAP) and positive expiratory pressure (PEP) therapy randomly applied in upright and lateral position. Spatial and temporal ventilation distribution was assessed.

RESULTS

The proportion of ventilation directed to the dependent lung significantly increased in lateral position compared to upright in healthy and CF. This effect was enhanced with CPAP but neutralised with PEP, whereas the effect of PEP was larger in the healthy group. Temporal ventilation distribution showed exactly the opposite with homogenisation during CPAP and increased inhomogeneity with PEP.

CONCLUSIONS

PEP shows distinct differences to CPAP with respect to its impact on ventilation distribution in healthy adults and CF subjects EIT might be used to individualise respiratory physiotherapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Riedel, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

André Schaller

Date Deposited:

27 Jan 2015 12:05

Last Modified:

28 Nov 2020 02:25

Publisher DOI:

10.1371/journal.pone.0106591

PubMed ID:

25222606

BORIS DOI:

10.7892/boris.62191

URI:

https://boris.unibe.ch/id/eprint/62191

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