Poly(ethylene oxide)-b-poly(3-sulfopropyl methacrylate) block copolymers for calcium phosphate mineralization and biofilm inhibition.

Mai, Tobias; Rakhmatullina, Ekaterina; Bleek, Katrin; Boye, Susanne; Yuan, Jiayin; Völkel, Antje; Gräwert, Marlies; Cheaib, Zeinab; Eick, Sigrun; Günter, Christina; Lederer, Albena; Lussi, Adrian; Taubert, Andreas (2014). Poly(ethylene oxide)-b-poly(3-sulfopropyl methacrylate) block copolymers for calcium phosphate mineralization and biofilm inhibition. Biomacromolecules, 15(11), pp. 3901-3914. American Chemical Society 10.1021/bm500888q

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Poly(ethylene oxide) (PEO) has long been used as an additive in toothpaste, partly because it reduces biofilm formation on teeth. It does not, however, reduce the formation of dental calculus or support the remineralization of dental enamel or dentine. The present article describes the synthesis of new block copolymers on the basis of PEO and poly(3-sulfopropyl methacrylate) blocks using atom transfer radical polymerization. The polymers have very large molecular weights (over 10(6) g/mol) and are highly water-soluble. They delay the precipitation of calcium phosphate from aqueous solution but, upon precipitation, lead to relatively monodisperse hydroxyapatite (HAP) spheres. Moreover, the polymers inhibit the bacterial colonization of human enamel by Streptococcus gordonii, a pioneer bacterium in oral biofilm formation, in vitro. The formation of well-defined HAP spheres suggests that a polymer-induced liquid precursor phase could be involved in the precipitation process. Moreover, the inhibition of bacterial adhesion suggests that the polymers could be utilized in caries prevention.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Restorative Dentistry, Research
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Rakhmatullina, Ekaterina; Cheaib, Zeinab; Eick, Sigrun and Lussi, Adrian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1525-7797

Publisher:

American Chemical Society

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

29 Jan 2015 11:17

Last Modified:

25 Jan 2017 12:15

Publisher DOI:

10.1021/bm500888q

PubMed ID:

25230392

BORIS DOI:

10.7892/boris.62223

URI:

https://boris.unibe.ch/id/eprint/62223

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