Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment

Welle, M.M.; Bley, C. R.; Howard, J.; Rüfenacht, S. (2008). Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment. Veterinary dermatology, 19(6), pp. 321-339. Blackwell Science 10.1111/j.1365-3164.2008.00694.x

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Mast cells (MCs) are well known for their neoplastic transformation in solitary and multiple cutaneous mast cell tumours (MCTs), as well as visceral and systemic mastocytosis. Dogs have a unique risk of developing cutaneous MCTs, and they account for 7% to 21% of all canine skin tumours. The aetiology of canine MCTs is unknown but is probably multifactorial. This article reviews up-to-date knowledge on the pathogenesis, the clinical presentation, the clinical prognostic factors, the diagnostic workup including clinical staging, cytological findings, histological findings and the various grading systems which have been evaluated based on morphology, the assessment of proliferation markers and other factors such as vessel density. Furthermore, detailed information about current treatment protocols for canine cutaneous MCTs is provided.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Central Clinical Laboratory
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Dermatology

UniBE Contributor:

Welle, Monika Maria; Howard, Judith and Rüfenacht, Silvia

ISSN:

0959-4493

Publisher:

Blackwell Science

Language:

English

Submitter:

Judith Howard

Date Deposited:

29 Jan 2015 11:42

Last Modified:

30 Jan 2015 21:34

Publisher DOI:

10.1111/j.1365-3164.2008.00694.x

PubMed ID:

18980632

BORIS DOI:

10.7892/boris.62286

URI:

https://boris.unibe.ch/id/eprint/62286

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