Effect of irradiation distance on image contrast in epi-optoacoustic imaging of human volunteers

Held, Kai Gerrit; Preisser, Stefan; Akarçay, Hidayet Günhan; Peeters, Sara Elisa; Frenz, Martin; Jaeger, Michael (2014). Effect of irradiation distance on image contrast in epi-optoacoustic imaging of human volunteers. Biomedical optics express, 5(11), pp. 3765-3780. Optical Society of America 10.1364/BOE.5.003765

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In combined clinical optoacoustic (OA) and ultrasound (US) imaging, epi-mode irradiation and detection integrated into one single probe offers flexible imaging of the human body. The imaging depth in epi-illumination is, however, strongly affected by clutter. As shown in previous phantom experiments, the location of irradiation plays an important role in clutter generation. We investigated the influence of the irradiation geometry on the local image contrast of clinical images, by varying the separation distance between the irradiated area and the acoustic imaging plane of a linear ultrasound transducer in an automated scanning setup. The results for different volunteers show that the image contrast can be enhanced on average by 25% and locally by more than a factor of two, when the irradiated area is slightly separated from the probe. Our findings have an important impact on the design of future optoacoustic probes for clinical application.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Institute of Applied Physics

UniBE Contributor:

Held, Kai Gerrit; Preisser, Stefan; Akarçay, Hidayet Günhan; Peeters, Sara Elisa and Frenz, Martin

Subjects:

600 Technology > 620 Engineering

ISSN:

2156-7085

Publisher:

Optical Society of America

Language:

English

Submitter:

Martin Frenz-Lips

Date Deposited:

05 Feb 2015 11:09

Last Modified:

05 Oct 2015 09:06

Publisher DOI:

10.1364/BOE.5.003765

BORIS DOI:

10.7892/boris.62362

URI:

https://boris.unibe.ch/id/eprint/62362

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