Clinical decision rules and D-Dimer in venous thromboembolism: current controversies and future research priorities

Rodger, Marc A.; Le Gal, Gregoire; Wells, Philip; Baglin, Trevor; Aujesky, Drahomir; Righini, Marc; Palareti, Gualtiero; Huisman, Menno; Meyer, Guy (2014). Clinical decision rules and D-Dimer in venous thromboembolism: current controversies and future research priorities. Thrombosis research, 134(4), pp. 763-768. Elsevier 10.1016/j.thromres.2014.07.031

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Venous thromboembolism (VTE) is a potentially lethal clinical condition that is suspected in patients with common clinical complaints, in many and varied, clinical care settings. Once VTE is diagnosed, optimal therapeutic management (thrombolysis, IVC filters, type and duration of anticoagulants) and ideal therapeutic management settings (outpatient, critical care) are also controversial. Clinical prediction tools, including clinical decision rules and D-Dimer, have been developed, and some validated, to assist clinical decision making along the diagnostic and therapeutic management paths for VTE. Despite these developments, practice variation is high and there remain many controversies in the use of the clinical prediction tools. In this narrative review, we highlight challenges and controversies in VTE diagnostic and therapeutic management with a focus on clinical decision rules and D-Dimer.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine

UniBE Contributor:

Aujesky, Drahomir

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0049-3848

Publisher:

Elsevier

Language:

English

Submitter:

Patricia Rajaonina

Date Deposited:

23 Jan 2015 14:19

Last Modified:

09 Nov 2015 10:49

Publisher DOI:

10.1016/j.thromres.2014.07.031

PubMed ID:

25129416

Uncontrolled Keywords:

Clinical Decision Rules, D-dimer, Diagnosis,Prognosis, Treatment, Venous Thromboembolism

BORIS DOI:

10.7892/boris.62478

URI:

https://boris.unibe.ch/id/eprint/62478

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