Split for the cure: VEGF, PDGF-BB and intussusception in therapeutic angiogenesis

Gianni-Barrera, Roberto; Bartolomeo, Mariateresa; Vollmar, Brigitte; Djonov, Valentin; Banfi, Andrea (2014). Split for the cure: VEGF, PDGF-BB and intussusception in therapeutic angiogenesis. Biochemical Society transactions, 42(6), pp. 1637-1642. Portland Press 10.1042/BST20140234

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Therapeutic angiogenesis is an attractive strategy to treat patients suffering from ischaemic conditions and vascular endothelial growth factor-A (VEGF) is the master regulator of blood vessel growth. However, VEGF can induce either normal or aberrant angiogenesis depending on its dose localized in the microenvironment around each producing cell in vivo and on the balanced stimulation of platelet-derived growth factor-BB (PDGF-BB) signalling, responsible for pericyte recruitment. At the doses required to induce therapeutic benefit, VEGF causes new vascular growth essentially without sprouting, but rather through the alternative process of intussusception, or vascular splitting. In the present article, we briefly review the therapeutic implications of controlling VEGF dose on one hand and pericyte recruitment on the other, as well as the key features of intussusceptive angiogenesis and its regulation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Djonov, Valentin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0300-5127

Publisher:

Portland Press

Language:

English

Submitter:

Ruslan Hlushchuk

Date Deposited:

09 Feb 2015 14:22

Last Modified:

06 Nov 2015 10:49

Publisher DOI:

10.1042/BST20140234

PubMed ID:

25399582

BORIS DOI:

10.7892/boris.62653

URI:

https://boris.unibe.ch/id/eprint/62653

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