Avian area vasculosa and CAM as rapid in vivo pro-angiogenic and antiangiogenic models.

Makanya, Andrew; Styp-Rekowska, Beata; Dimova, Ivanka; Djonov, Valentin (2014). Avian area vasculosa and CAM as rapid in vivo pro-angiogenic and antiangiogenic models. In: Ribatti, Domenico (ed.) Vascular Morphogenesis. Methods in Molecular Biology: Vol. 1214 (pp. 185-196). New York: Humana Press 10.1007/978-1-4939-1462-3_11

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Angiogenesis, the development of new blood vessels from preexisting ones, is driven by coordinated signaling pathways governed by specific molecules, hemodynamic forces, and endothelial and periendothelial cells. The processes involve adhesion, migration, and survival machinery within the target endothelial and periendothelial cells. Factors that interfere with any of these processes may therefore influence angiogenesis either positively (pro-angiogenesis) or negatively (antiangiogenesis). The avian area vasculosa (AV) and the avian chorioallantoic membrane (CAM) are two useful tools for studying both angiogenesis and antiangiogenesis since they are amenable to both intravascular and topical administration of target, agents, are relatively rapid assays, and can be adapted very easily to study angiogenesis-dependent processes, such as tumor growth. Both models provide a physiological setting that permits investigation of pro-angiogenic and antiangiogenic agent interactions in vivo.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Makanya, Andrew; Dimova, Ivanka and Djonov, Valentin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1064-3745

ISBN:

978-1-4939-1461-6

Series:

Methods in Molecular Biology

Publisher:

Humana Press

Language:

English

Submitter:

Ruslan Hlushchuk

Date Deposited:

09 Feb 2015 14:14

Last Modified:

26 Feb 2016 15:01

Publisher DOI:

10.1007/978-1-4939-1462-3_11

PubMed ID:

25468605

BORIS DOI:

10.7892/boris.62655

URI:

https://boris.unibe.ch/id/eprint/62655

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