Patho-genetics of Clostridium chauvoei

Frey, Joachim; Falquet, Laurent (2015). Patho-genetics of Clostridium chauvoei. Research in microbiology, 166(4), pp. 384-392. Elsevier 10.1016/j.resmic.2014.10.013

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The genomic sequence of Clostridium chauvoei, the etiological agent of blackleg, a severe disease of ruminants with high mortality specified by a myonecrosis reveals a chromosome of 2.8 million base-pairs and a cryptic plasmid of 5.5 kilo base-pairs. The chromosome contains the main pathways like glycolysis/gluconeogenesis, sugar metabolism, purine and pyrimidine metabolisms, but the notable absence of genes of the citric acid cycle and deficient or partially deficient amino acid metabolism for Histidine, Tyrosine, Phenylalanine, and Tryptophan. These essential amino acids might be acquired from host tissue damage caused by various toxins and by protein metabolism that includes 57 genes for peptidases, and several ABC transporters for amino acids import.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

UniBE Contributor:

Frey, Joachim

Subjects:

600 Technology > 630 Agriculture
500 Science

ISSN:

0923-2508

Publisher:

Elsevier

Language:

English

Submitter:

Amandine Ruffieux

Date Deposited:

09 Feb 2015 16:21

Last Modified:

31 Oct 2018 11:47

Publisher DOI:

10.1016/j.resmic.2014.10.013

PubMed ID:

25445013

Uncontrolled Keywords:

Blackleg, Virulence, Toxins, Metabolic pathway, Host–pathogen interactions, Mode of replication

BORIS DOI:

10.7892/boris.62663

URI:

https://boris.unibe.ch/id/eprint/62663

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