The rabbit blood shunt subarachnoid haemorrhage model.

Marbacher, Serge; Fathi, Ali Reza; Muroi, Carl; Coluccia, Daniel; Andereggen, Lukas; Neuschmelting, Volker; Widmer, Hans Rudolf; Jakob, Stephan; Fandino, Javier (2015). The rabbit blood shunt subarachnoid haemorrhage model. Acta neurochirurgica - supplementa, 120, pp. 337-342. Springer 10.1007/978-3-319-04981-6_58

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The recently introduced rabbit blood shunt subarachnoid haemorrhage model is based on the two standard procedures of subclavian artery cannulation and transcutaneous cisterna magna puncture. An extracorporeal shunt placed in between the arterial system and the subarachnoid space allows examiner-independent SAH in a closed cranium. Despite its straightforwardness, it is worth examining some specific features and characteristics of the model. We outline technical considerations to successfully perform the model with minimal mortality and morbidity. In addition, we discuss outcome measures, advantages and limitations, and the applicability of the model for the study of early brain injury and delayed cerebral vasospasm after SAH.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Jakob, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0065-1419

Publisher:

Springer

Language:

English

Submitter:

Alessandra Angelini

Date Deposited:

16 Feb 2015 10:59

Last Modified:

29 Oct 2015 09:25

Publisher DOI:

10.1007/978-3-319-04981-6_58

PubMed ID:

25366648

URI:

https://boris.unibe.ch/id/eprint/62794

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