Indium-111 labeled gold nanoparticles for in-vivo molecular targeting.

Ng, Quinn Kwan-Tai; Olariu, Cristina I; Yaffee, Marcus; Taelman, Vincent F; Marincek, Nicolas; Krause, Thomas Michael; Meier, Lorenz; Walter, Martin Alexander (2014). Indium-111 labeled gold nanoparticles for in-vivo molecular targeting. Biomaterials, 35(25), pp. 7050-7057. Elsevier 10.1016/j.biomaterials.2014.04.098

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The present report describes the synthesis and biological evaluation of a molecular imaging platform based on gold nanoparticles directly labeled with indium-111. The direct labeling approach facilitated radiolabeling with high activities while maintaining excellent stability within the biological environment. The resulting imaging platform exhibited low interference of the radiolabel with targeting molecules, which is highly desirable for in-vivo probe tracking and molecular targeted tumor imaging. The indium-111 labeled gold nanoparticles were synthesized using a simple procedure that allowed stable labeling of the nanoparticle core with various indium-111 activities. Subsequent surface modification of the particle cores with RGD-based ligands at various densities allowed for molecular targeting of the αvß3 integrin in-vitro and for molecular targeted imaging in human melanoma and glioblastoma models in-vivo. The results demonstrate the vast potential of direct labeling with radioisotopes for tracking gold nanoparticles within biological systems.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Klinische Radiopharmazie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Klinische Radiopharmazie

UniBE Contributor:

Ng, Quinn Kwan-Tai; Olariu, Cristina; Taelman, Vincent; Marincek, Nicolas; Krause, Thomas Michael; Meier, Lorenz and Walter, Martin Alexander

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0142-9612

Publisher:

Elsevier

Language:

English

Submitter:

Franziska Nicoletti

Date Deposited:

30 Mar 2015 15:47

Last Modified:

20 Mar 2018 13:23

Publisher DOI:

10.1016/j.biomaterials.2014.04.098

PubMed ID:

24840614

Uncontrolled Keywords:

Molecular imaging Nanomedicine RGD, cell tracking, α(v)ß(3) integrin

BORIS DOI:

10.7892/boris.62824

URI:

https://boris.unibe.ch/id/eprint/62824

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