Current management options for liposarcoma and challenges for the future

Kollár, Attila; Benson, Charlotte (2014). Current management options for liposarcoma and challenges for the future. Expert review of anticancer therapy, 14(3), pp. 297-306. Expert Reviews 10.1586/14737140.2014.869173

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Liposarcoma (LS) represents one of the most common soft tissue sarcomas. There are three major subtypes, namely, well/dedifferentiated, myxoid/round cell and pleomorphic LS. In general, LS is known to be a relatively chemo-resistant sarcoma subtype with the exception of the myxoid variant. Conventional chemotherapy with doxorubicin and ifosfamide represents the mainstay of systemic treatment in the first line. Other active cytotoxic agents include gemcitabine and docetaxel and the marine-derived compounds trabectedin. Recent progress in molecular diagnostics of each single LS subtype has improved the knowledge of the molecular characteristics and has led to two recent treatment targets: the amplification of mouse double minute 2 homolog and cyclin-dependent kinase-4 in well- and dedifferentiated LS. Thus far, only early-phase trials are reported and no new drugs have been introduced in daily clinical practice. The focus of this review is on current systemic treatment options, including novel strategies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Kollár, Attila

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1473-7140

Publisher:

Expert Reviews

Language:

English

Submitter:

Monique Ryter

Date Deposited:

10 Feb 2015 13:57

Last Modified:

27 Aug 2015 10:48

Publisher DOI:

10.1586/14737140.2014.869173

PubMed ID:

24397249

BORIS DOI:

10.7892/boris.62867

URI:

https://boris.unibe.ch/id/eprint/62867

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